Genetic influences on brain structure - imaginggenetics.org.pdfVIP

articles Genetic influences on brain structure 1 2 1 2 3 Paul Thompson , Tyrone D. Cannon , Katherine L. Narr , Theo van Erp , Veli-Pekka Poutanen , 4 4 3 3 Matti Huttunen , Jouko Lönnqvist , Carl-Gustaf Standertskjöld-Nordenstam , Jaakko Kaprio , 1 1 1 1 Mohammad Khaledy , Rajneesh Dail , Chris I. Zoumalan and Arthur W. Toga 1 Laboratory of Neuro Imaging and Brain Mapping Division (Rm. 4238, Reed Neurological Research Center), Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, California 90095-1769, USA 2 Departments of Psychology, Psychiatry, and Human Genetics, UCLA School of Medicine [Author: Please provide full mailing address.] 3 Department of Radiology, University of Helsinki [Author: Please provide full mailing address.] 4 Department of Mental Health and Alcohol Research, National Public Health Institute of Finland [Author: Please provide full mailing address.] 5 Department of Public Health, Universities of Helsinki and Oulu [Author: Please provide full mailing address.] Correspondence should be addressed to P.T. (thompson@) Published online: xxxx, DOI: 10.1038/ xxxx Here we report on detailed three-dimensional maps revealing how brain structure is influenced by individual genetic differences. A genetic continuum was detected, in which brain structure was increasingly similar in subjects with increasing genetic affinity. Genetic factors significantly influenced cortical structure in Bro