Evaluation of radioprotective efficacy and possible mechanism.pdfVIP

e n v i r o n m e n t a l t o x i c o l o g y a n d p h a r m a c o l o g y 3 1 ( 2 0 1 1 ) 427–435 a v a i la b le at ww w.scie ncedirect. com j o u rn al h omepage: www.elsevi er.c om /locate/etap Evaluation of radioprotective efficacy and possible mechanism of action of Aloe gel Dinesh Kumar Saini, Mali Ram Saini ∗ Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004, Rajasthan, India a r t i c l e i n f o a b s t r a c t Article history: The present study was undertaken to determine the optimum effective dose, dose reduction Received 27 August 2010 factor (DRF) and possible mechanism of action of Aloe gel. Three different doses of gel (250, Received in revised form 500 and 750 mg/kg body weight) were tested against 8 Gy induced damage in Swiss albino 20 January 2011 mice. A dose of 750 mg/kg body weight of Aloe was found the most effective while, 250 mg/kg Accepted 9 February 2011 body weight was the least effective in providing protection, as observed in the form of higher Available online 18 February 2011 concentrations of blood GSH and vitamin C and lower level of serum LPO than irradiated animals at 1 h post irradiation and higher percent of survivors up to day 30 post irradiation. Keywords: Treatment of mice with Aloe before irradiation with different doses of gamma radiation Aloe gel (6–12 Gy) delayed the onset and reduced the severity of signs of radiation sickness. The Effective dose