Human papillomavirus (HPV) test and PAP smear as predictors of outcome in conservatively treated adenocarcinoma in situ (AIS) of the uterine cervix》.pdfVIP

Gynecologic Oncology 106 (2007) 170 – 176 /locate/ygyno Human papillomavirus (HPV) test and PAP smear as predictors of outcome in conservatively treated adenocarcinoma in situ (AIS) of the uterine cervix Silvano Costa a,⁎, Giovanni Negri b , Mario Sideri c , Donatella Santini d , Giuseppe Martinelli d , Simona Venturoli e , Carla Pelusi a , Stina Syrjanen f , Kari Syrjanen g , Giuseppe Pelusi a a Department of Obstetrics and Gynecology, S. Orsola-Malpighi Hospital, via Massarenti 13, 40138 Bologna, Italy b Department of Pathology, Central Hospital, Bolzano, Italy c Department of Gynecology Oncology, European Institute of Oncology, Milano, Italy d Department of Pathology, S. Orsola-Malpighi Hospital, Bologna, Italy e Department of Clinical and Experimental Medicine, Section of Microbiology, University of Bologna, Bologna, Italy f Department of Oral Pathology, Institute of Dentistry, University of Turku, Finland g Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland Received 20 January 2007 Available online 4 May 2007 Abstract Objective. The present study assessed (i) the clinical outcome of patients with conservatively treated cervical adenocarcinoma in situ (AIS), (ii) the accuracy of diagnosing AIS by cytology, colposcopy and histology, as well as (iii) the performance of cervical cytology and HPV testing in detection of residual or re