Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes》.pdfVIP

General and Comparative Endocrinology 210 (2015) 124–129 Contents lists available at ScienceDirect General and Comparative Endocrinology journal homepage: www.else /locate/ygcen Review Endoplasmic reticulum stress is involved in the connection between inflammation and autophagy in type 2 diabetes Han Liu, Ming-ming Cao, Yang Wang, Le-chen Li, Li-bo Zhu, Guang-ying Xie, Yan-bo Li ⇑ Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, No. 23 You zheng Street Nan Gang District, Harbin 150001, China a r t i c l e i n f o a b s t r a c t Article history: Type 2 diabetes is a chronic inflammatory disease. A number of studies have clearly demonstrated that Received 31 May 2014 cytokines such as interleukin 1b (IL1b) contribute to pancreatic inflammation, leading to impaired glu- Revised 30 August 2014 cose homeostasis and diabetic disease. There are findings which suggest that islet b-cells can secrete Accepted 16 September 2014 cytokines and cause inflammatory responses. In this process, thioredoxin-interacting protein (TXNIP) is Available online 27 September 2014 induced by endoplasmic reticulum (ER) stress, which further demonstrates a potential role for ER stress in innate immunity via activation of the NOD-like receptor (NLRP) 3/caspase1 inflammasome and in dia- Keywords: betes pathogenesis via the release of cytokines. Recent developments hav