Electrospun curcumin-loaded fibers with potential biomedical applications》.pdfVIP

Carbohydrate Polymers 94 (2013) 147–153 Contents lists available at SciVerse ScienceDirect Carbohydrate Polymers j o u r n a l h o m e p a g e : w w w. elsev /locate/car bpol Electrospun curcumin-loaded fibers with potential biomedical applications Xiao-Zhu Sun a , Gareth R. Williams b , Xiao-Xiao Hou a , Li-Min Zhu a,∗ a College of Chemistry Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, PR China b UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK a r t i c l e i n f o a b s t r a c t Article history: Polyvinyl alcohol (PVA) nanofibers loaded with curcumin or its -cyclodextrin (CD) inclusion complex Received 28 September 2012 were successfully prepared using an electrospinning process. The influence of curcumin or CD–curcumin Received in revised form complex content on fiber formation and quality was investigated. X-ray diffraction and differential scan- 10 December 2012 ning calorimetry analyses of the fibers, together with electron microscope evidence, demonstrated that Accepted 26 December 2012 curcumin is likely to be present as crystalline aggregates in the fibers, while its CD complex is more evenly Available online 3 January 2013 distributed. 1H NMR analysis indicated that the chemical structure of curcumin was preserved during the electrospinning process. Thermogravimetric analysis demonstrated that inclusion into nanofibers Key