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Effect of tiotropium on neural respiratory drive during exercise in severe COPD》.pdf
Pulmonary Pharmacology Therapeutics 30 (2015) 51e56 Contents lists available at ScienceDirect Pulmonary Pharmacology Therapeutics journal homepage: /locate/ypupt Effect of tiotropium on neural respiratory drive during exercise in severe COPD a, 1 b, 1 c, 1 a a a Yin-Yin Qin , Rui-Fa Li , Guo-Feng Wu , Zheng Zhu , Jie Liu , Cheng-Zhi Zhou , Wei-Jie Guan a, Jia-Ying Luo a, Xin-Xin Yu a, Yang-Ming Ou a, Mei Jiang a, Nan-Shan Zhong a, **, Yuan-Ming Luo a, * a State Key Laboratory of Respiratory Diseases, The First Affi liated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory, Guangzhou Institute of Respiratory Disease, 151 Yanjiang Road, Guangzhou, Guangdong, 510120, China b ShenZhen Nanshan Peoples Hospital, Shenzhen, Guangdong, 518052, China c Li-Wan Hospital of Guangzhou Medicine University, Guangzhou, Guangdong, 510170, China a r t i c l e i n f o a b s t r a c t Article history: Background: Studies have shown that tiotropium once daily reduces lung hyperinflation and dyspnea Received 10 June 2014 during exercise and improves exercise tolerance in patients with COPD. Mechanisms underlying the Received in revised form effects of the muscarinic receptor antagonist tiotropium on COPD have not been fully understood. 17 November 2014 Objective: In this study, we investigated whe
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