溃平宁胃内漂浮片的制备工艺研究.pdf

·制 剂 工 艺 Western Journal of Traditional Chinese Medicine,2015 Vol.28 No.5 溃平宁胃内漂浮片的制备工艺研究 王宝才，刘效栓，李喜香 甘肃省中医院，甘肃 兰州 730050 ［摘 要］目的：以溃平宁提取物为模型药物，应用 HPMC、十八醇、PEG、MCC 为核心辅料，筛选出优化的胃 内漂浮片的制备工艺，并探讨中药在胃滞留漂浮型缓控释制剂中的应用。 方法：采用均匀设计法，以漂浮性能 和释放度作为考察指标，对处方进行优化。 结果：优化处方为溃平宁提取物∶A(混合辅料，由 HPMCK-4M 和 HPM- CK-100M 组成，各占 50%)∶PEG6000∶MCC∶十八醇为 100∶17∶10.12∶5∶22。 结论：该制剂具有良好的漂浮性能和缓释 效果。 ［关键词］溃平宁胃内漂浮片；均匀设计；释放度；漂浮性能 ［中图分类号］R943.41 ［文献标识码］A ［文章编号］1004-6852(2015)05-0040-04 The Preparation of KuiPingNing Gastric Floating Tablets WANG Baocai, LIU Xiaoshuan, LI Xixiang Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China Objective: To screen the preparation of optimum gastric floating tablets by taking KuiPingNing ex- tract as the model and HPMC, octadecanol, PEG, MCC as core materials, at the same time to discuss the application of herbs to controlled release preparation remained floating in stomach. Methods: Homogeneous design was adopted to optimize the formulation by taking floatability and release rate as the factors. Results: Optimal formulation was KuiPingNing extract: A (the mixed adjuvant materials, containing HPMCK-4M and HPMCK-100M, 50% respectively): PEG 6 000: octadecanol (100: 17: 10.12: 5: 22). Conclusion: The formulation shows good floatability and con- trolled-release effect. KuiPingNing gastric floating tablets; homogeneous design; release rate; floatability 胃滞留漂浮型缓控释制剂是根据流体力学平 司)。 衡原理 (HBS)设计制备，是一种不崩解的亲水性凝 1.2 试药 溃平宁提取物 (自制)购于四川新荷 胶骨架制剂。 该剂型能使药物口服后迅速漂浮于 花 中 药 饮 片 股 份 有 限 公 司 ， 符 合《中 国 药 典》 胃液之上