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NRF2的抗氧化作用,电机对nrf的影响,抗氧化剂的作用,抗氧化的作用,抗氧化剂的作用机理,抗氧化物质的作用,硫酸锌的抗氧化作用,抗氧化胶囊的作用,抗氧化护眼片的作用,具有抗氧化作用的药物
Acta Pharmacol Sin 2007 Sep; 28 (9): 1409 1421
Invited review
Cancer chemoprevention by phytochemicals: potential molecular targets,
biomarkers and animal models1
Ki Han KWON2,3, Avantika BARVE2,4, Siwang YU2,3, Mou-Tuan HUANG2,5, Ah-Ng Tony KONG2,3,6
2 Center f or Cancer P revention R esearch, 3D ep artment of Pharmaceutics, 4 Graduate Prog ram in P harmaceutical Science, 5Susan L ehman
Cullman Laboratory f or Cancer Research, D ep artment of Chemical B iology, Ernest M ario School of Pharmacy , Rutg ers, The State University
of New Je rsey, P iscataway, NJ 08854, USA
Key words Abstract
chemoprevention; dietary cancer chemopre- Recent studies have strongly indicated that certain daily-consumed dietary
v ent iv e comp ou nd s ; n u clear fa ctor E 2-
phytochemicals could have cancer protective effects against transgenic mice can-
r elated factor 2 ; nu clear factor -k app aB;
act iv at or p r ot ein - 1; m it og en -a c ti v at ed cer models and cancers mediated by carcinogens, irradiations and carcinogenic
protein kinases metabolites derived from exogenous or endogenous sources. The cancer-protec-
tive effects elicited by these dietary compounds are believed to be due at least in
1 This study was supported in part by Institu- part to the induction of cellular defense systems including the detoxifying and
tional Fund s and by RO 1-CA094828, RO 1- antioxidant enzymes system, as well as the inhibition of anti-inflammatory and
CA 0 9 2 5 15 , R O1- CA 0 7 3 6 74 an d R 0 1- anti-cell growth signaling pathways culminating in cell cycle arrest and/or cell-
CA1 18947 to Dr Ah-Ng Tony KONG from
the N ational In stitutes of Health (NIH). death. In this review, we summarize the potential mechanisms including the modu-
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