挤出-滚圆法制备盐酸文拉法辛缓释胶囊及体外释放性考察.pdfVIP

698 Med 军事医学2012年9月第36卷第9期MilSci，Vol36，No9，Sep，2012 挤出一滚圆法制备盐酸文拉法辛缓释胶囊及体外释放性考察 姚亮元1’2，粱逸曾1 [摘要] 目的 制备盐酸文拉法辛缓释胶囊并考察其体外释药特性。方法采用挤出一滚圆法制备盐酸文拉法 辛素丸，采用EudragitNE30D水分散体作为成膜材料，流化床底喷法对素丸进行包衣，单因素考察对处方和工艺进 行筛选和优化。结果挤出一滚圆法制备的丸芯粒度分布16～30目，缓释包衣增重为22％～30％时，与上市品(怡 诺思@)释放速率基本一致，4种包衣增重的f2值分别为68、78、71和50。结论该方法制备的盐酸文拉法辛缓释 胶囊处方和制备工艺可靠，重现性好。 [关键词]盐酸文拉法辛；挤出一滚圆法；微丸；流化床；迟效制剂 [中图分类号]R944 [文献标志码]A · [文章编号]1674—9960(2012)09-0698-04 venlafaxine of sustained-releaseand release Preparation hydrochloride capsulesdrug invitro YAO Liang．yuanl’-．LIANGYi-zen91。 South PharmaceuticalStock (1．Central Joint University，Changsha410083，China；2．HunanQianjinXian西iang Co．，Ltd．， Zhuzhou，Hunan412011，China) $Correspondingauthor，TelE—mail：yly733@163．con To venlafaxine extendedrelease and the release [Abstract]Objective prepare hydrochloride capsulesinvestigatedrug invitro．Methods wasusedto uncoated NE30Dasex— Extrusion—spheronizationtechnique prepare pellets．UsingEudragit tendedfilm werecoatedWurstfluidbed methodwasusedtoselectand material，the pellets by technique．Single·factor op— timizethe and The sizeoftheuncoated from16to30 pelletpropertiestechnology．Resultsparticle pelletsranged mesh， increasedto22％-30％．thereleaseratewas thesameasthemarketed ER@” coatingweight drug basically product”Effexor andthevalueoffour was and Thismethodfor extend—