制备透明质酸衍生物交联剂的应用研究.pdfVIP

·70 · Ch inese J Reparative and Reconstructive Surgery, 2004, V o l 18( 1) 制备透明质酸衍生物交联剂的应用研究 1# 2 1 2 陈景华 　林　枞 　顾其胜 　徐　政 　　【摘　要】　　 目的　综述近年来国内外有关制备透明质酸衍生物交联剂的研究, 为研制开发新型透明质酸提供选 择。　方法　查阅国内外相关文献, 对制备透明质酸衍生物交联剂的种类和特性、交联方法、交联机制进行综合分析。　 结果　利用各种交联剂对透明质酸进行修饰, 所得到的透明质酸衍生物保留了透明质酸良好的生物相容性, 且流变学特 性发生了改变, 使其在组织内的存留时间延长。　结论　透明质酸衍生物的开发大大地拓展了透明质酸在医学领域的 应用。 【关键词】　　透明质酸　　衍生物　　交联剂 中图分类号: 31808　 9774 R R - RESEARCH OF CROSS L INK ING REAGENT FOR PROD UC ING HYAL URON IC AC ID D ER IVATIVE CH EN J ing , , , . . , . . 201106, : hua L in Cong GU Q i sheng et al S hang hai Q isheng B iom aterial Institu te S hang hai P R Ch ina E m ail qish @shqisheng. com 【 】　　 　 Abstract Objective To review the recent advances of cro ss link ing reagent fo r p roducing hyaluronic acid (HA ) derivative so as to p rovide mo re advice fo r the developm ent of HA reagent. M ethods　R ecent o riginal articles , , related to the species characteristic cro ss link ing m ethodo logy and m echanism of the cro ss link ing reagent to p roduc . 　 ing HA derivative w ere summ arized and system atically analyzed Results T he derivatives after special k inds of reagents modification w ould rem ain their ow n good biocompatibility and change their o riginal rheo lo lgical characterization and . 　 obtain relativ