对牙槽骨再生的影响.pdfVIP

齐鲁医学杂志 2004 年 12 月第 19 卷第 6 期　Med J Qilu , December 2004 , Vol. 19 , No. 6 4·81 · rhBMP2 与聚乳酸复合体植入犬拔牙创 对牙槽骨再生的影响 高 　宁 ,李宁毅 ,贾暮云 ,商红国 (青岛大学医学院附属医院口腔科 , 山东 青岛　266003) [摘要] 　①目的 　观察重组基因骨形态发生蛋白2 (rhBMP2) 与聚乳酸的复合体植入犬拔牙创对牙槽骨再生 的影响。②方法 　犬拔牙创内充填 rhBMP2 与聚乳酸的复合体 , 以自然愈合拔牙创作为对照,于术后 2 、6 、10 周行 X 线检查 ,6 、10 周处死犬 ,取标本行光镜和扫描电镜观察成骨情况、复合体与新生骨结合情况。③结果 　X 线检查 及病理检查结果显示实验侧拔牙创愈合快 ,成骨速度及成骨质量明显优于对照侧。电镜扫描显示该材料相容性 好 ,对组织无刺激反应 ,可降解。④结论 　rhBMP2 与聚乳酸复合体是一种可促进牙槽骨再生的新型生物复合材 料 ,有希望成为临床修复牙槽骨缺损的新型材料。 [ 关键词] 　聚乳酸 ;骨形态发生蛋白 ;拔牙 ;牙槽窝 [ 中图分类号] 　R782. 13 　　[文献标识码] 　A 　　[文章编号] (2004) EFFECTS OF FILLING EXTRACTION SOCKET WITHrhBMP2/ POLYLACTIC ACID COMPOUND ON THE REGENERATION OF ( AL VEOLAR BONE IN DOGS 　GA O Ni ng , L I Ni ngyi , JIA M uyun , et al 　 Department of Stomatology , The Affiliated Hospital of Qingdao University Medical College , Qingdao 266003 ,China) ABSTRACT 　Objective 　To observe the effects of rhBMP2/ polylactic acid compound filling into extraction socket on the regen eration of alveolar bone in dogs. 　Methods 　rhBMP2/ polylactic acid compound was implanted into extraction sockets. The normal heal ing extraction sockets were served as controls. Xray examination was performed at 2 , 6 , and 10 weeks after the operation. The do gs were killed at 6 and 10 weeks , and a light microscopy and a scanning electronic microscopy used to evaluate the effects of composite on the regeneration of alveolar bone. 　Results 　Compared with the control side , the extraction sockets filled with compound healed better , more bone was regenerated. 　Conclusion 　rhBMP2/ polylactic acid compound may serve as a new biological material to improve the re