白细胞介素_12临床应用研究进展.pdfVIP

2007 1 14 1 CH IN J CANCE R PREV TREAT , January 2007, Vol14 No1 75 综述 讲座 12 宋舸, 袁玫, 卢世璧 中国人民解放军总医院骨科研究所, 北京100853 Study of int erleukin12 clinical uses SON G Ge, Y UA N Mei, L U Shibi I ns titute of Orthop aed ics, General H osp ital of Chinese Peop le s L iberation A rm , Beij ing 100853, P. R. China ! ∀ 白细胞介素12( IL12) [ ABSTRACT] Interleu in12 ( IL12) previously called cyt otoxic lympho 最初称作自然杀伤细胞刺激因子 cyte maturation factor ( CLMF) or NK cell stimulatory factor ( NKSF) is a ( NKSF) 或细胞毒性淋巴细胞成 recently charact erized het erodimeric cyt o ine composed of tw o subunits 熟因子( CLMF) , 一种异二聚体 IL12 has demonst rated remar able antitumor activity w hen used direct ly as a 细胞因子直接使用重组蛋白 recombinant protein or w hen different viral or nonviral vectors transfer its IL12 或转基因载体都有显著的 genes At enhancing tumor immunit y, IL12 acts as a bridge between innate 抗肿瘤作用, 它通过诱发 NK, and adapt ive immune responses due to its ability to induce proliferat ion and NKT 和 T 细胞增殖活化而介导 activation of NK, NKT , and T cells In addition, IL12 inhibits tumor angio 主动和被动免疫保护反应除此 genesis mainly through IFNgammadependent production of the chemo ine 之外, 通过趋化因子 IP10 诱生 IP10 In experimental tumor models, recombinant IL12 treatment has a IFN阻止肿瘤血管发生在动 dramat ic ant i tumor effect on transplantable tumors, on chemically induced 物肿瘤模型中, IL12 对移植瘤 tumors, and in tumors arising spontaneously in genetically modified mice 化学诱变瘤及自发肿瘤均有明显 T he stimulating activity of IL12 on ant igenspecif ic immunity relies mostly 治疗作用IL12 可以刺激抗原 on its ability to determine or augment T h1 and cytot oxic T lymphocyte re 特异性免疫反应而促进T h1 和