控释微丸国内外研究进展.pdfVIP

·药学专论· 年 月 日 第 卷第 期 ２０１４ １０ ５ ２３ １９ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｍｏｎｏｇｒａｐｈｓ China Pharmaceuticals Vol.23,No.１9,October5,20１４ 控释微丸国内外研究进展 潘 伦，江尚飞，谭小梅，刘应杰，何 静，杨宗发 （重庆医药高等专科学校药学院，重庆 ４0１33１） 摘要：查阅近年来国内外控释微丸的研究进展的相关文献，并分析、归纳不同种类控释释微丸的特点、所选用的辅料、制备工艺及微丸 压片技术。随着现代制备工艺的逐渐成熟及辅料的发展，控释微丸成为目前缓控释制剂发展的重要方向。 关键词：控释微丸；释药机制；进展 中图分类号： 文献标识码： 文章编号： ( ) R944．9 A 1006-4931 2014 19-0008-04 Researc Progress of Controlled Release Micro Pill at Ｈome and Abroad Ｐan Ｌun, Ｊiang Sｈangfｅi, Ｔan Ｘiaoｍｅi, Ｌiu Ｙingｊiｅ, Ｈｅ Ｊing, Ｙang Ｚongfa (Cｈongqing Mｅｄiｃaｌ anｄ Ｐｈaｒｍaｃｅuｔiｃaｌ Coｌｌｅgｅ, Cｈongqing, Cｈina 401331 Abstract:The related literature of the research progress of controlled release micro pill at home and abroad in recent years is consult- ed.The characteristics of different kinds of controlled release micro pill, selected auxiliary materials, preparation technology and pellet tabletting technique are analyzed and summarized.Along with the gradual maturity of the preparation technology and the development of auxiliary materials,the controlled release micro pill has become the important direction of controlled release preparation development at present. Key words:controlled release micro pill;mechanism of drug release;progress 控释微丸是指将药物与阻滞剂混合制丸或先制成普通丸芯 1 骨架型微丸 后包缓控释衣膜而制备的小型丸剂[１ （ ） ，其直径为0.5~１.5 mm。 骨架型微丸是由药物、骨架材料 阻滞剂 和致孔剂等组成。