血清胱抑素C在诊断妊娠高血压疾病早期肾损伤中的价值.docVIP

血清胱抑素C在诊断妊娠高血压疾病早期肾损伤中的价值 徐建民 任天凤 云浮市妇幼保健院检验科 527300 【摘要】目的 探讨血清胱抑素C在妊娠高血压疾病患者早期肾损害诊断的价值。方法 分别对67例妊娠高血压疾病患者（其中妊娠高血压组40例，子痫前期组27例）、50例正常妊娠晚期妇女（正常晚期妊娠组）及30例健康体检的非妊娠妇女（正常非妊娠组）血清中胱抑素C(CysC)，尿素（Urea）、肌酐（Cr）、尿素（UA）及尿蛋白进行检测。结果 妊娠高血压组和产前子痫组的CysC均高于正常晚期妊娠组和正常非妊娠组，产前子痫组的CysC又高于妊娠高血压组，产前子痫组血清Urea、Cr、UA、尿蛋白测定值与各组比较均有明显增高，而其他各组之间比较差异无统计意义。结论 血清CysC是一种反应肾小球滤过功能较敏感的指标，在诊断妊娠高血压疾病中具有较好的早期肾损伤诊断价值。 【关键词】 胱抑素C；妊娠高血压疾病；早期肾损伤 Value of serum cystatin C in early renal induced by hypertensive disorder complicating pregnancy Xu Jian-min,Ren Tian-feng, Laboratory Examination Dept. , Yunfu Maternity Child Care Hospital,527300 【bstract】 bjective To investigate the value of the serum cystatin C in early renal damage in patients with pregnancy-induced hypertension disease. Methods The serum levels of cystatin C (CysC), Urea (Urea), creatinine (Cr), Urea (UA) and urinary protein were detected respectively on 67 patients with pregnancy-induced hypertension disease (40 patients with gestational hypertension group, 27 cases with preeclampsia group), 50 cases of normal late pregnancy women (normal late pregnancy group) and 30 cases of healthy check-up of non pregnant women (no pregnancy group). Results The measured value of CysC of gestational hypertension group and preeclampsia group were higher than normal late pregnancy group and no pregnancy group. The value of CysC, Urea, Cr and UA, urine protein measurements in preeclampsia group were significantly increased compared with each group, and there was no statistically significant difference between the other groups. Conclusion Serum CysC is a reaction as a glomerular filtration function sensitive indicator that has good diagnostic value of early renal damage. 【key words】cystatin C; Pregnancy-induced hypertension disease; Early renal damage Pregnancy-induced hypertension disease），是妊娠期的特发性疾病，常发生于妊娠晚期，肾脏氧耗高，对缺氧及灌注不足最敏感，是妊娠高血压病最早受累器官之一 [1]。因此早发现、早诊断妊娠高血压疾病患者肾功能损害和早治疗将有利于改善母儿的预后。本研究通过比较正常非孕妇女，正常晚期妊娠妇女及妊娠综合征的孕妇血清CysC、Urea、Cr、UA、尿蛋白的指标的变化，探讨CysC在妊娠