SOD模拟及其抗氧化和抗炎症功能研究进展.pdfVIP

21 5 化 学 进 展 Vol. 21 No. 5 2009 5 PROGRESS IN CHEMISTRY May, 2009 SOD 模拟及其抗氧化和抗炎症功能的研究进展* 1 1 2 1* * 胡 平 吴耿伟 夏 青 毛宗万 ( 1. 中山大学化学与化学工程学院生物无机与合成化学教育部重点实 室有害生物控制与 资源利用国家重点实 室 广州510275; 2. 北京大学药学院 北京100191) 超氧化物歧化酶( s peroxide dism tase, 简称SOD) 作为生物体内超氧离子自由基的清除剂, 具 备有效抗氧化抗炎症抗衰老之功效, 并用于临床, 其化学模拟引起了人们的广泛研究兴趣本文将简要 介绍近年来SOD 人工模拟酶及其生物医学活性研究所取得的重要进展, 特别是 C , ZnSOD 模拟物结构与 功能的相互关系MnSOD 模拟物的生物活性及其医学应用 超氧化物歧化酶 SOD 模拟物 抗氧化 抗炎症 : Q55 : A : 1005281X( 2009) Achievement in SOD Mimics with Antioxidant and AntiInflammation Functions 1 1 2 1* * H u Ping Wu Gengwei X ia Qing Mao Zongwan ( 1.MOE Key Laboratory of Bioinorganic and Synthetic Chemistrythe State Key Laboratory for Biological Control, School of Chemistry and Chemical Engineering, S n YatSen University, G angzho 510275, China; 2. School of Pharmace tical Sciences, Peking University Health Science Center, Beijing 100191, China) Abstract As effective radical scavengers in vivo, s peroxide dism tases ( SODs) have the antioxidant, anti inflammation and antiaging f nctions, and have been applied in clinical treatments as dr gs. Therefore, there is still an increasing interest in design and development of artificial SODs for potential application. In this article, a brief introd ction abo t the research achievement of SOD mimics and their biomedical activities d ring past decade is shown. O r attention foc ses on the relation between the str ct re and biological f nction of C , ZnSOD mimics as well as the bioactivity and application of MnSOD mimics in medicine. Key words s peroxide dism tase( SOD) ; SOD mimics; antioxid