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BMC Cancer BioMed Central Research article Open Access Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk † † Lara Bethke , Emily Webb , Gabrielle Sellick, Matthew Rudd, Stephen Penegar, Laura Withey, Mobshra Qureshi and Richard Houlston* Address: Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK Email: Lara Bethke - lara.bethke@icr.ac.uk; Emily Webb - emily.webb@icr.ac.uk; Gabrielle Sellick - gabrielle.sellick@icr.ac.uk; Matthew Rudd - matthew.rudd@icr.ac.uk; Stephen Penegar - stephen.penegar@icr.ac.uk; Laura Withey - laura.withey@icr.ac.uk; Mobshra Qureshi - mobshra.qureshi@icr.ac.uk; Richard Houlston* - richard.houlston@icr.ac.uk * Corresponding author †Equal contributors Published: 5 July 2007 Received: 23 June 2006 Accepted: 5 July 2007 BMC Cancer 2007, 7:123 doi:10.1186/1471-2407-7-123 This article is available from: /1471-2407/7/123 © 2007 Bethke et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones. Methods: To inves
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