骨性关节炎生物学标记物软骨寡聚基质蛋白的研究进展.pdfVIP

714 Chinese Journal of Reparative and Reconstructive Surgery, June 2010, Vol. 24, No.6 · · 骨性关节炎生物学标记物软骨寡聚基质蛋白的研究进展 白伦浩 王瑜 张田鹏 【摘  要】 目的 综述骨性关节炎（osteoarthritis，OA ）生物学标记物软骨寡聚基质蛋白（cartilage oligomeric matrix protein ，COMP ）的研究进展。  方法 广泛查阅近年来关于COMP 的文献，并对其进行分析。  结果 COMP 是 目前广泛研究的OA 生物学标记物之一，研究认为COMP 与OA 的发生、发展具有相关性，是目前所研究的生物标记物中 可以持续表达并预测进程的最佳标记物。  结论 COMP 在OA 发病机制中的确切作用仍不清楚，采用COMP 作为手段 早期诊断OA 需进一步深入研究。 【关键词】    软骨寡聚基质蛋白 骨性关节炎 生物标记物 中图分类号： R684.3 Q816 文献标志码：A RESEARCH PROGRESS OF CARTILAGE OLIGOMERIC MATRIX PROTEIN/BAI Lunhao, WANG Yu, ZHANG Tianpeng. Department of Spine and Joint, Shengjing Hospital, China Medical University, Shenyang Liaoning, 110001, P.R.China. Corresponding author: BAI Lunhao, E-mail: bailh@ 【Abstract 】    Objective To review the research progress of cartilage ol igomeric matrix protein (COMP). Methods Domestic and abroad l iterature about COMP was reviewed and summarized. Results COMP was one of the osteoarthritis (OA) biomarkers of being widely studied. Most studies in recent years could draw the conclusion that COMP was associated with OA. COMP was the foremost biomarker among investgated biomarkers. It could been continuously expressed and predicted knee OA progression. Conclusion Precisely what role COMP plays in OA pathogenesis remains unclear, using COMP as a tool to early diagnose OA more studies would be needed. 【Key words 】 Cartilage oligomeric matrix protein Osteoarthritis Biomarker 3 骨性关节炎（osteoarthritis，OA ）是常见疾病和慢 （80 ～100）× 10 ，亚单位间通过二硫键相连接。电镜 性致残的首要因素，被WTO 列为21 世纪严重影响人 下可见COMP 分子由5 个可弯曲的臂通过卷曲的N 类生存质量的疾病之一。OA 不仅给患者带来极大痛 末端连结组成。COMP 基因约