脑部定量核磁共振灌注成像-------外文翻译.docVIP

脑部定量核磁共振灌注成像：脑卒中的初步结果 Quantitative Cerebral MR Perfusion Imaging: Preliminary Results in Strok 脑部定量核磁共振灌注成像：脑卒中的初步结果 Purpose:? To evaluate? quantitative? cerebral? blood? ?ow (qCBF) with traditional time-based measurements or metrics of cerebral perfusion: time to peak (Tmax) and mean transit time (MTT) in stroke patients. Materials? and? Methods:? Nine? ischemic? stroke? patients (four male, ?ve female, 63 6 16 years old) were included in the study which was Health Insurance Portability and Accountability?? Act?? compliant?? and?? institutional?? review board approved. Cerebral perfusion was quanti?ed using the? Bookend? method.? Mean? values? of? qCBF, Tmax,? and MTT were determined in regions of interest (ROIs). ROIs were drawn on diffusion weighted images in diffusion positive,? critically ischemic? (CI),? in? ipsilateral normal? region immediately? surrounding? the? critically? ischemic? region,the presumed penumbra (PP), and in contralateral diffusion? negative? control,? presumed? normal? region? (PN)? of gray and white matter separately (GM and WM). 目的：采用传统的基于时间的脑灌注测量或度量方法，定量评估脑血流量：脑卒中病人脑血流量的达峰的时间(Tmax)和平均通过时间(MTT)。 材料和方法：经过了机构审查委员会批准并遵循医疗保险便利及责任法案，本研究纳入9名缺血性脑卒中病人（4名男性，5名女性，年龄为63±16）。使用书夹法对脑灌注进行定量分析。测定了感兴趣区域（ROIs）的脑血流量均值、最大峰值时间和平均通过时间。感兴趣区域包括弥散阳性区以及严重缺血区域的弥散加权成像，迅速波阿伟严重缺血区域的同侧征程区域，假定半影区，并且以对侧弥散阴性区域以及灰质和白质的假定正常区作为对照。 Results:? In? both? GM? and? WM,? qCBF? measures? distinguished the studied brain regions with the most markedly reduced values in regions corresponding to extent of likely ischemic injury. In planned comparisons, only qCBF measurements differed signi?cantly between CI and PP tissues.ROC analysis supported the utility of qCBF for discriminating brain regions differing in the likely extent of ischemic injury (CI and PN regions – qCBF: area under the curve [AUC]? ?? 0.96,? Tmax:? AUC? ?? 0.96,? MTT:? AUC? ?? 0.72).Importantly, qCBF afforded the best discrimination of CI and PP regions (qCBF: AUC ? 0.82, Tmax: AUC ? 0.65,MTT: AUC ? 0.52). 结果：在灰质和白