新加良附颗粒对S180荷瘤小鼠生存期的影响.docVIP

 新加良附颗粒对 S180 荷瘤小鼠生存期的影 响# 周义浪1，吴晓勇2，侯丽1，田劭丹1，陈信义1** 5 10 15 20 25 30 35 40 （1. 北京中医药大学东直门医院肿瘤血液科，北京 100700； 2. 贵阳中医学院第一附属医院肿瘤血液科，贵州贵阳 550001） 摘要：目的：观察新加良附颗粒对 S180 荷瘤小鼠生存期的影响。方法：采用腹腔注射法建 立 S180 腹水瘤小鼠模型，以新加良附颗粒低、中、高剂量及其联合 5-氟尿嘧啶为治疗药物， 观察对 S180 腹水瘤小鼠生存期及生命延长率的影响。结果：新加良附颗粒高剂量组及其低、 中、高剂量组联合 5-氟尿嘧啶组的生命延长率分别为 28.25％、46.33％、59.89％、70.06％； 与模型对照组比较，有统计学意义（P＜0.05，P＜0.01）。结论：新加良附颗粒对 S180 荷 瘤小鼠生存期具有延长效果，各剂量组联合 5-氟尿嘧啶能够明显延长 S180 荷瘤小鼠生存期。 关键词：胃癌；新加良附颗粒；S180 荷瘤；生存期；生命延长率 中图分类号：R273 The Effects of Modified Liang-Fu Granules on Survival Period of S180 Tumor Bearing Mice ZHOU Yilang1, WU Xiaoyong2, HOU Li1, TIAN Shaodan1, CHEN Xinyi1 (1. Department of Oncology and Hematology,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700; 2. Department of Oncology and Hematology, The first Affiliated Hospital of GuiYang college of Traditional Chinese Medicine, Guizhou Guiyang 550001) Abstract: Objective: To observe the effects of Modified Liang-Fu Granules(MLFG) on survival period of S180 tumor bearing mice. Methods: The establishment of S180 ascites tumor model by intraperitoneal injection S180 tumor cells,which were administrated by MLFG in high, medium, low doses and combined with 5-fluorouracil respectively, then observing the effect of MLFG on survival period and life-prolonging rate of S180 tumor bearing mice. Results: The life-prolonging rate of MLFG in high dose group and MLFG in low, medium, high doses combined with 5-FU group was 28.25%,46.33%,59.89%,70.06% respectively; Compared with the model control group, there were statistically significant (P0.05，P0.01). Conclusion: MLFG could prolong the survival period of S180 tumor bearing mice, and the different-dose of MLFG combined with 5-FU could prolong the survival time of S180 tumor bearing mice significantly. Key words: gastric cancer;Modified Liang-Fu Granules;S180 tumor bearing mice;survival period; life-prolonging rate 0 引言 新加良附颗粒由清·谢元庆《良方集腋》的良附丸加穿山龙组成，有温中散 寒、行气止痛之功效。我们既往体外抑瘤实验表明，新加良附颗粒对人肝癌细胞 （BEL- 7402）