YY1在乳腺癌复发转移中作用的研究.docVIP

 YY1 在乳腺癌复发转移中作用的研究# 刘姝伶，张清媛，武海燕，王静萱，赵文辉，卢康平** （哈尔滨医科大学附属第三医院，哈尔滨，150080） 5 摘要：目的 探讨正常乳腺组织、乳腺癌原发病灶及乳腺癌复发转移灶中 YY1 的表达及其 临床意义。方法 采用免疫组织化学 S-P 法检测 56 例乳腺癌原发病灶及其对应的复发后二 次手术的乳腺癌转移灶，以及 20 例正常乳腺组织中 YY1 的表达情况，并分析其与 ER、PR、 C-erbB-2、ki67、P53 等多个乳腺癌相关因子及临床病理参数的关系。结果 乳腺癌复发转 10 移灶中 YY1 的阳性表达率为 78.6%（44/56），显著高于乳腺癌原发病灶的 51.8%（29/56） 及正常乳腺组织的 25.0%（5/20），差异有统计学意义(P0.05)。YY1 的表达与乳腺癌组织 学分级、TNM 分期及腋窝淋巴结转移相关（P0.05），而与患者的年龄、肿瘤大小无关 ( P0.05 )；YY1 的表达与 ER 表达呈负相关（P0.05），与 C-erbB-2、ki67 表达呈正相关 （P0.05），而与 PR、P53 表达无明显的相关性( P0.05 )。结论 YY1 的高表达预示着肿 15 20 25 30 35 瘤具有较高的侵袭性和转移性，YY1 有望成为乳腺癌治疗的新靶点。 关键词： 乳腺癌；YY1；复发转移；免疫组织化学 中图分类号：R73 The research about the role of YY1 in recurrence and metastasis of breast cancer LIU Shuling, ZHANG Qingyuan, WU Haiyan, WANG Jingxuan, ZHAO Wenhui, LU Kangping (The third hospital of Harbin medical university,Harbin,150080) Abstract: Objective Measuring the expression of YY1 in normal breast tissues, primary breast cancer lesions and metastasis lesions of breast cancer. To study the correlation between the expression of ER、PR、C-erbB-2、ki67、P53 and YY1. To investigate the role of YY1 in metastasis of breast cancer. Methods The expression of YY1 was detected in primary cancer tissues, breast tissues of 56 patients with breast cancer and normal breast tissues of 20 patients with benign breast tissues by immunohistochemical staining. The 56 patients were analyzed according to clinical stage and the number of axillary lymph node.Results The positive rate of YY1 in metastasis lesions of breast cancer was 78.6%（44/56）, it was significantly higher than primary breast cancer lesions51.8%（29/56）and normal breast tissues25.0%（5/20）(P0.05). There was a positive correlation between breast cancer tissue grades, TNM, axillary lymph node metastasis and the expression of YY1（P0.05）,there was no correlation between age, the size of tumor and the expression of YY1 ( P0.05). YY1 had a negative correlation with ER（P0.05）, a positive correlation with C-erbB-2、ki67, and