固肾安胎丸联合低分子肝素干预复发性流产妇女血栓前状态的疗效.docVIP

固肾安胎丸联合低分子肝素干预复发性流产妇女血栓前状态的疗效 韩宁 许雅娟 郑州大学第三附属医院产科 X 关注成功！ 加关注后您将方便地在 我的关注中得到本文献的被引频次变化的通知！ 新浪微博 腾讯微博 人人网 开心网 豆瓣网 网易微博 摘????要： 目的 观察固肾养胎丸 (何首乌、地黄、肉苁蓉, 等) 联合低分子肝素 (LMWH) 治疗血栓前状态 (PTS) 所致复发性流产 (RSA) 的临床疗效。方法 126例PTS所致RSA患者随机分为观察组与对照组63例, 对照组采用LMWH治疗, 观察组在对照组基础上加用固肾安胎丸, 疗程持续到妊娠20周。观察2组有效率, 治疗前后凝血-纤溶指标变化, 治疗后随访比较2组妊娠结局。结果 治疗后对照组总有效率73.0%, 观察组87.3%, 2组比较有显著性差异 (P0.05) ;治疗后, 2组纤维蛋白原 (FIB) 、D-二聚体 (D-D) 、纤溶酶原激活物抑制物1 (PAI-1) 水平有显著改善 (P0.05) , 观察组治疗效果好于对照组 (P0.05) ;对照组妊娠成功率69.8%, 观察组85.7%, 观察组显著高于对照组 (P0.05) 。结论 固肾安胎丸联合LMWH治疗血栓前状态所致复发性流产安全有效, 可显著改善血液高凝状态, 改善妊娠结局。 关键词： 固肾安胎丸; 低分子肝素; 复发性流产; 血栓前状态; 作者简介：韩宁 (1978—) , 女, 硕士生, 从事中西医结合治疗妇产科疾病研究。E-mail:hling1111@ 作者简介：许雅娟 (1963—) , 女, 主任医师, 从事高危妊娠方面的研究。E-mail:cnzzzsl@163.com 收稿日期：2017-05-09 基金：常州四药临床药学科研基金 (CZSYJJ16037) Gushen Antai Pills combined with low-molecular-weight heparin treating prethrombotic state of women with recurrent spontaneous abortion HAN Ning XU Ya-juan Department of Obstetrics, The Third Hospital Affiliated to Zhengzhou University; Abstract： AIM To observe the clinical effects of Gushen Antai Pills (Polygoni multiflori Radix, Rehmanniae Radix, Cistanches Herba, etc.) combined with low-molecular-weight heparin (LMWH) in treating women with recurrent spontaneous abortion (RSA) due to coagulation disorder (prethrombotic state, PTS) . METHODS One hundred and twenty-six cases of RSA patients in PTS were randomly assigned to observation group and control group for the treatment of either LMWH combined with Gushen Antai Pills or LMWH. The trial went on during the first twenty weeks of pregnancy. Investigations on total treatment efficiency, coagulation-fibrinolysis indicator levels before and after treatment were conducted, and results of follow-ups were compared as well. RESULTS The total effective rate of 73. 0% in the control group and 87. 3% in the observation group displayed a significant difference (P 0. 05) . Although the levels of fibrinogen (FIB) , D-dimer (D-D) and plasminogen activator inhibi