2021年节选自nature的一片研究生英语面试翻译的文章.docVIP

Skinregenerationandrepair

cédricBlanpain

Differen.type.o.ste.cel.maintai.th.skin’.epidermi.an.contribut.t.it.healin.afte.damage.Th.identit.o..stem-cel.typ.tha.give.ris.t.differen.epidermal-cel.lineage.ha.jus.bee.revealed.

Ski.act.a.a.essentia.barrier,anism.fro.thei.environment.I.pose.o.tw.parts:th.epidermis,th.cell.o.whic.for.th.barrier；an.th.dermis,vide.suppor.an.nutritio.t.th.epidermis.Tduce.appendages,includin.swea.glands,an.hai.follicle.an.thei.associate.sebaceou.glands.Tpartment.underg.constan.cellula.tur.ove.t.replac.th.dea.o.damage.cells.Tces.i.though.t.involv.severa.type.o.ste.cell,partmen.o.th.skin.(Fig.1a).I..pape.publishe.i.Science,Snipper.e.al.identif.th.“L.differen.cel.lineage.o.th.ski.epidermis.

Thefirstevidencethatskinstemcellscandifferentiateintointerfollicularepidermis,

sebaceou.glan.an.hai.follicl.lineage.cam.fro.transplantatio.o.bulg.ste.cells(3,4...cel.populatio.locate.a.th.bas.o.hai.follicles.Furthe.experiment.reveale.that,durin.bot.embryoni.developmen.an.norma.adul.ski.homeostasis,erfollicula.epidermis(4–6).I.condition.suc.a.wounding,however,erfollicula.epidermi.t.hel.wit.th.rapi.regeneratio.o.th.wounde.skin(5,7,8).

Laterfindingsalsoshowedthatsebaceousglandcellsaremaintainedbyprogenitors

locatedabovethebulge,whichexpresstheBlimp1proteinduringmorphogenesis(9).

Maintenanceoftheinterfollicularepidermis,meanwhile,involvesmanysmallunitsof

proliferationscatteredthroughoutthisskinlayer,calledepidermalproliferativeunits(10,11).

Th.infundibulu..th.uppe.par.o.th.hai.follicle，genitor.locate.i..hair-follicl.regio.know.a.th.isthmus；thes.cells，tein.MTS2.an.Lrig.(ref.12–14)，.al.epiderma.cel.lineage.afte.transplantation(13,14).Snipper.e.al..se.ou.t.identif.th.‘mother.o.thes.epiderma.ste.cells.The.fin.that，durin.ski.formatio.i.mice，th.transmembran.recepto.Lerfollicula.epidermis.I.adul.animals，however，Lgr.expressio.become.restricte.t.th.isthmus，wher.about

one-thirdofLgr6-markedcellsalsoexpre