细胞生物学课件：Chapter 5 Endomembrane System or Intracellular compartment.pptxVIP

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细胞生物学课件：Chapter 5 Endomembrane System or Intracellular compartment.pptx

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A common feature for lysosomal enzymes： ----containing mannose-6- phosphate (M6P, 6-磷酸甘露糖) in its oligosaccharide chain， ----The receptor of lysosomal enzymes specifically binding to M6P;N-乙酰葡萄糖胺磷酸转移酶;signal patch (信号斑) ：存在于完成折叠的蛋白质中，由几个信号序列折叠在一起构成的三维结构。;溶酶体酶合成及糖基化修饰;PLANT CELL VACUOLES;2.Characteristics of endomembrane system;Vesicle transport --transport way of proteins and lipids;3.Biological significance of endomembrane systems forming some functionally specialized compartments ----provide microenvironment within the cel for varieties of biochemical reactions. ----raising reactive efficiency by improving important molecular concentration. improving its regulatory capacity by enlarging membrane area of metabolism, which provides attachment bracket for the;Function as a intracellular membrane system ----all the membrane is synthesized and assembled uniformly, thereby keeping intracellular membrane structure in agreement. ----intercoordination in function—group- like management ---- membrane traffic (膜流) by the secretory and endocytic pathways 膜流k（emeempbsranceeflllolws oryomuemtbhrfaunuel-t-r-aMfefmibcra）n：e 细胞的各种膜结t构r相an互sf联o系rm和at转i移on现.象称为膜流。内质网至高尔基体膜流，高尔基体至内质网的反向膜流—不仅有物质运输，还存在膜的转换。;思考题;Chapter 6 Ribosome， synthesis and transport of proteins;Ribosome: structure and function Transport of proteins Fate of proteins;1. Ribosome (核糖体);1)Ribosome structure;(2)Chemical component of ribosomes Each subunit consists of rRNAs and proteins RNAs inside the subunit, proteins over the surface (The proteins of the small subunit is named as S1, S2, and the proteins of the large subunit is named as L1, …..).;(31);;16S rRNA：1457-1544 nt，the conserved sequence of ACCUCCUUA at the 3′end is complementary with the purine-rich SD sequence.;5S rRNA (细菌)：120 or 116 nt, two highly conserved sequences, one CGAAC sequence may recognise tRNA, the other may interact with GTψCG sequence of TΨC loop. 5.8S rRNA：160nt，the;Compositions of ribosome from different sources;2) Biogenesis of Ri