不对称羟胺化反应.pptxVIP

不对称羟胺化反应第1页/共22页 Hisashi Yamamoto was born in Kobe, Japan, in 1963. He received his Bachelor’s degree from Kyoto University in 1967, where he got his start in a research group headed by Prof. H. Nozaki. Professor Yamamoto received his Ph.D. from Harvard University under mentorship of Corey. Yamamoto has become aware of the importance of chiral Lewis acids in asymmetric synthesis. In 1985, he first introduced binaphthol as a ligand for chiral Lewis acid catalysts. This work was the forerunner of a vast amount of present-day research on the binaththol based chiral Lewis acid catalyst. More recently, silver catalyzed ene and aldol reactions were reported which are remarkably effective in a series of asymmetric transformations. To date, Professor Yamamoto has co-authored over 400 publications and 100 reviews.Hisashi Yamamoto第2页/共21页第2页/共22页 Hisashi Yamamoto’s outstanding work on nitroso aldol recation[1]. Momiyama, N.; Yamamoto, H. Angew. Chem. Int. Ed. 2002, 41, 2986.[2]. Momiyama, N.; Yamamoto, H. J. Am. Chem. Soc. 2003, 125, 6038.[3]. Momiyama, N.; Yamamoto, H. J. Am. Chem. Soc. 2005, 127, 1080.[4]. Momiyama, N.; Torii, H.; Saito, S.; Yamamoto, H. Pans 2005, 101, 5374.[5]. Yamamoto Y.; Momiyama, N.; Yamamoto, H. J. Am. Chem. Soc. 2004, 126, 5962.[6]. Momiyama, N.; Yamamoto, H. Org.Lett 2004, 126, 5962.[7]. Momiyama, N.; Yamamoto, H. J. Am. Chem. Soc. 2004, 126, 5360.第3页/共21页第3页/共22页 Armando Cordova : The Arrhenius Laboratory of Stockholm University[1]. B?gevig, A.; Sundén, H.; Córdova, A. Angew. Chem. Int. Ed. 2004, 43, 1109.[2]. Córdova, A .; Johansson, M.; B?gevig, A.; Sundén, H.; Chem. Eur. J. 2004, 10, 3673.[3]. Sundén, H.; Dahin, N.; Ibrabem, I.; Adolfsson, H.; Córdova, A. Teterahedron. Letters. 2005, 46, 3385.第4页/共21页第4页/共22页 手性lewis酸催化的a-胺氧化反应Angew. Chem .Int. Ed 2002, 41, 2986Yamamoto’s workYield:37-94%第5页/共21页第5页/共22页 Yamamoto’s workJ. Am . Chem. Soc 2003,125, 6038第6页/共21页第6页/共22页 Yamamoto’s workJ. Am . Chem. Soc 2005,127,1080第7页/共21页第7页/共22页