SNIPERs-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf免费

SNIPERs IAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers Specific and Non-genetic inhibitor of apoptosis protein [IAP]-dependent Protein Erasers (SNIPER), a class of small-molecule degraders, is designed to induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins. SNIPERs recruit IAP family of RING-type E3 ligases-cIAP1, cIAP2, and XIAP. The SNIPER chemical structure consists of selective IAP antagonist (i.e., Bestatin, MV1, and LCL161), PEG linker and peptide- or small-molecule-based protein of interest (POI)-specific component. Unlike the chimeric molecules that recruit von Hippel-Lindau and cereblon ubiquitin ligases, SNIPERs induce simultaneous degradation of IAPs such as cIAP1 and XIAP along with the target proteins. www.MedChemE 1 SNIPERs Inhibitors Biotin-BS BzNH-BS Cat. No.: HY-111879 Cat. No.: HY-111878 Biotin-BS contains two different ligands, BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and biotin, which methyl-bestatin (MeBS) for cIAP1 and are connected by linkers. MeBS as a ligand for benzoyl-amide, which are connected by linkers. cellular inhibitor of apoptosis protein 1 (cIAP1) MeBS as a ligand for cellular inhibitor of ubiquitin ligase. apoptosis protein 1 (cIAP1) ubiquitin ligase.