MAPKAPK2-MK2-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf

MAPKAPK2 (MK2) Mitogen-activated protein kinase activated protein kinase 2; MAP kinase activated protein kinase 2; MAPK activated protein kinase 2; MAPKAP kinase 2 MAP kinase-activated protein kinase 2 (MAPKAPK2) is an enzyme that in humans is encoded by the MAPKAPK2 gene. MAPKAP kinase-2 (MK2) is originally identified by its phosphorylation of glycogen synthase at serine-7 and the corresponding serine in a peptide (GS peptide-1) modelled after the N-terminus of glycogen synthase. MAPKAP kinase-2 is a novel protein kinase activated by mitogen-activated protein kinase. This MAP kinase activated protein kinase, termed MAPKAP kinase-2, is distinguished from S6 kinase-II (MAPKAP kinase-1) by its response to inhibitors, lack of phosphorylation of S6 peptides and amino acid sequence. www.MedChemE 1 MAPKAPK2 (MK2) Inhibitors CC-99677 CMPD1 Cat. No.: HY-139504 Cat. No.: HY-108643 CC-99677 is a potent, covalent, and irreversible CMPD1 is a selective and non-ATP-competitive p38 inhibitor of the mitogen-activated protein (MAP) MAPK-mediated MK2 phosphorylation inhibitor with kinase-activated protein kinase-2 (MK2) pathway apparent K (K app) of 330nM. i i in both biochemical (IC50 =156.3 nM) and cell based assays (EC50 =89 nM). CC-99677 is extracted from patent WO2020236636, compound 1.