Trk-Receptor-Inhibitors-Modulators-生命科学试剂-MedChemExpress.pdf免费

Trk Receptor Tropomyosin related kinase receptor Trk receptors are a family of three receptor tyrosine kinases (TrkA, TrkB, and TrkC), each of which can be activated by one or more of four neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4). TrkA, TrkB, and TrkC are transmembrane proteins that comprise the TRK receptor family. These receptor tyrosine kinases are expressed in human neuronal tissue, and play an essential role in both the physiology of development and function of the nervous system through activation by neurotrophins (NTs). The latter are specific ligands known as NGF for TrkA, BDGF, and NT-4/5 for TrkB and NT3 for TrkC, respectively. The binding of the ligand to the receptor triggers the oligomerisation of the receptors and phosphorylation of specific tyrosine residues in the intracytoplasmic kinase domain. This event results into the activation of signal transduction pathways leading to proliferation, differentiation and survival in normal and neoplastic neuronal cells. www.MedChemE 1 Trk Receptor Inhibitors, Agonists, Activators Antagonists (R)-Larotrectinib 7,8-Dihydroxyflavone ((R)-LOXO-101; (R)-ARRY-470) Cat. No.: HY-12866B Cat. No.: HY-W013372 (R)-Larotrectinib is a potent TRK inhibitor with 7,8-Dihydroxyflavone is a potent and selective an IC50 value of 28.5 nM for TrkA. TrkB agonist that mimics the physiological (R)-Larotrectinib can be used for researching