病理学与病理生理学 消化系统疾病 病毒性肝炎（双语学习）.pptxVIP

Hepatitis Song Wen-gang Department of Pathology Luohe Medical College December 4, 2014 Content Vocabulary Hepatitis References Vocabulary Hepatitis HBV = hepatitis B virus HBsAg = hepatitis B surface antigen Casey was diagnosed with hepatitis B in 2003. Vocabulary biopsy Pathology Microscopically, hepatitis B can produce all of the histologic features of acute and chronic hepatitis described earlier, but some liver biopsy specimens also display a particular morphologic feature that is nearly diagnostic, the ground glass. Pathology In chronic HBV infection, some hepatocytes may have viral genomes integrated into the host genome. If, by chance, the surface antigen gene integrates into a host genomic site adjacent to an active promoter, then the cell is converted into a factory for surface antigen production. Usually in such cells full viral replication does not take place. Since surface antigen can only exit the cell as part of intact viral particles, the antigen just accumulates in these cells, creating a large cytoplasmic inclusion consisting of endoplasmic reticulum stuffed with surface antigen that has a fine, smoothly granular appearance similar to that of ground glass. Reference Robbins Basic Pathology (9th Edition), 507