【乳腺疾病学习课件】_BENIGN BREAST DISEASES.ppt

BENIGN TUMOURS ? Duct Papillomad导管内乳头状瘤 Benign papillary epithelial tumour; occurs mainly in large ducts Papillae are fibrovascular stalks lined by layers of proliferating epithelial and myoepithelial cells Most patients present with a serous or bloody nipple discharge Nipple adenomas 乳头腺瘤 RELATIVE RISK FOR INVASIVE BREAST CANCER FOR BENIGN BREAST LESIONS RISK FOR INVASIVE BREAST CANCER v???? No Increased Risk (NIR) Mastitis Fat necrosis Mammary duct ectasia Non-proliferative (“fibrocystic”) disease Fibroadenoma (simple) RISK FOR INVASIVE BREAST CANCER v??Slightly ? Risk (SIR) = ? Risk 1.5-2 Times Moderate/florid hyperplasia Sclerosing adenosis Fibroadenoma (complex) Duct papilloma RISK FOR INVASIVE BREAST CANCER v??Moderately ?Risk (MIR) = ?Risk 4-5 Times Atypical ductal hyperplasia Atypical lobular hyperplasia Mondor’s disease Breast retraction caused by thrombophlebitis of the thoracoepigastric vein (Mondor’s disease). Nipple Retraction Slit-like nipple retraction from duct ectasia Nipple inversion from breast cancer Management of Gynecomastia 谢谢！ Jamaican Breast Disease Study 2000-2Biopsy Results (46.1% patients) CARCINOMA OF THE BREAST EPIDEMIOLOGY Commonest malignancy in women worldwide: Breast cancer 18% Cervical cancer 15% Colonic cancer 9% Stomach cancer 8%?? EPIDEMIOLOGY Incidence rates are highest in North America, Australia and Western Europe; intermediate in South America, the Caribbean and Eastern Europe and lowest in China, Japan and India Most common invasive tumour of Jamaican women RISK FACTORS ? Age Incidence of breast cancer ?ses with age Uncommon before age 25 years; incidence ?ses to the time of menopause and then slows RISK FACTORS ? ? Family History Approx 10% of breast cancer is due to inherited genetic predisposition A woman whose mother or sister has had breast cancer is at ?relative risk 2