泌尿系统生理学教学课件.ppt

Mechanism of the aldosterone effects H+ ATP K+ 4. Regulation of Renin Secretion Bleeding Juxtaglomerular cell Renin PGE2, PGI2, E , NE ⊕ ANGⅡ Vasopressin ANP NO ⊕ BP Blood volume Stretch stimulus (afferent A) Macula densa RBF Sympathetic nerve ⊕ - Juxtaglo-merular cell macula densa mesangial cell afferent A efferent A the distal tuble .ar/ci...leS.html Ⅲ Atrial Natriuretic Peptide (ANP) 1) GFR 2) Reabsorption of Na+ and H2O in collecting tubules 3) Renin, ANG Ⅱ, Vasopressin Part 3 Regulation of the Water Balance ⅠAntidiuretic Hormone ( ADH ) Vasopressin ( VP ) Secreted by supraoptic nucleus and paraventricular nucleus Stored in posterior pituitary Mechanism: influence expression of vasopressin- inducible water channel (AQP2) 1. Secretion and Effect of VP Fig Mechanism of the VP (ADH) Effects vasopressin-inducible water channel Water channel H2O reabsorption in the distal tubule and collecting duct ADH PermeabilityH2O in the distal tubule (VP) and collecting duct Effects of Vasopressin Permeabilityurea in the collecting duct ADH (VP) Plasma osmotic pressure the important physiological factor osmoreceptor: sensory threshold (280 mOsm/kg ? H2O) set point (resetting) Blood volume Blood pressure 2. Regulation of VP Secretion Factors influencing VP secretion: resetting of osmoreceptor threshold 1) Plasma Osmotic Pressure Sweating, Vomiting Diarrhea Posm ( plasma ) Osmoreceptor ⊕ PH2O in the distal tubule and collecting duct Water Reabsorption Urine VP Dehydration Thirs