中国医科大学妇产科学英文课件 Cervical cancer.pptVIP

Cervical tumor Introduction A group of precancerous lesion closely associated with the cervical cancer,which reflect the continuous process of the development of the cervical cancer. 1.CIN caused by virus infection rarely develop cervical cancer 2.CIN caused by multifactors may develop cervical cancer. 3.TBS diagnosing system by NCI (1).atypical squamous cells,ABC. (2).low-grade squamous intraepithelial lesion,LSIL. (3).high-grade squamous intraepithelial lesion ,HSIL. LSIL means CIN I,rarely develop cervical cancer. HSIL menas CIN II and III,may develop cervical cancer. Etiology HPV(human papillomaviruses) infection Epidemiologic risk factors for CIN: 1,multiple sexual partners 2,high-risk sexual partner 3,early onset of sexual activity(16) 4,a history of STDs(especially, HPV infection) 5,cigarette smoking 6,immunodeficiency 7,long-tem oral contraceptive pill use Cervical Histological Specialty (i).primal squamo-columnar junction (ii).physiologic squamo-columnar junction (iii).transformation zone (iv).squamous metaplasia (v).squamous epithelization Pathology Cervical intraepithelial neoplasia(CIN) degree I: ie,mild dysplasia, heterotype cells occupy lower 1/3 layer degree II: ie,moderate dysplasia, heterotype cells occupy the lower 2/3 layer degree III: ie,severe dysplasia and carcinoma in situ, heterotype cells occupy whole layer Clinical findings Usually no symptoms or signs Early detection is extremely important Diagnosis Repeated cervical ctyology--TCT Colposcopic examination Biopsy—the most reliable method to make diagnosis Treatment CINI:Cryotherapy can be used in small,limited lesions, with an effective rate of 95%.For lesions involving vagina or glands ,laser ablation is used with an effective rate of 93%. CINII:Cryotherapy(94% effective rate),laser ablation(92% effective rate) or cone excision can be used according to the range of les