SDHI类杀菌剂研究进展.ppt

* SDHI类杀菌剂的构效关系-小结 基本结构 cis-巴豆酰胺 γ 位氢键受体 展 望 1、重磅产品: -----杀菌谱、活性、对抗性菌有效 2、抗性管理： -----抗性治理、自身抗性 3、新品研发： -----负交互抗性、结构新颖化合物 * -THANKS- 谢谢！ * 呼吸链或称电子传递链，是由4个酶复合体，即复合体Ⅰ、Ⅱ、Ⅲ和Ⅳ组成的质子或电子传递体，是需氧生物获取和储存能量的关键。理论上，抑制任何一个复合体的活性都将导致生物体不能正常合成能量，进而衰竭死亡。目前全球第一大杀菌剂甲氧基丙烯酸酯类杀菌剂是抑制病原菌呼吸作用复合体Ⅲ，该类杀菌剂与SDHI类杀菌剂因作用位点不同而无交互抗性，所以两类杀菌剂常常复配使用，以延缓抗性的产生，并扩大了防治谱。 * 啶酰菌胺主要针对果蔬病害，如灰霉病、菌核病、早疫病，吡唑酰胺较啶酰菌胺杀菌谱扩大，如对小麦叶枯病和大豆锈病的活性，活性提高 * * * * * bixafen induces physiological changes in wheat plants such as synchronized the ear emergence, increased green leaf area duration, higher physiological activity of ears during grain filling due to delay of plant senescence. The combination of these effects resulted in a yield advantage of bixafen treated plants compared to the other fungicide treatments. 叶面和种子处理 氟唑菌酰胺销售峰值：6亿欧元 * 吡唑萘菌胺对三唑类和甲氧基丙烯酸酯类抗性品系病菌高效，尤其对壳针孢属(Septoria)真菌十分高效，如对小麦锈病和大麦锈腐病的防效均优于氟环唑。该杀菌剂以保护作用为主，但在田间试验中亦显示一定的治疗作用。其具有持效期长的特点，施药7周后仍表现出明显效果，其保护期要比三唑类杀菌剂长两周左右。 苯丙烯氟菌唑，high efficacy level against the soybean rust (Phakopsora pachyrhizi), it is also very active on other crops like cereals (Septoria tritici, Pyrenophora teres and Puccinia sp.), pome fruits (Venturia inequalis), potatoes (early blight), vegetables (powdery mildew, early blight, anthracnose), corn (Puccinia sorghi, Cercospora zea-maydis), peanuts (Puccinia arachidis, scelorotium rolfsii) and grapes (Uncinula necator). Solatenol is safe to the crop, also when applied with DMI and QoI compds * * Schematic overview of chemical structures of succinate dehydrogenase inhibitors (SDHIs). The amide bond is strictly conserved across all SDHIs and defines the orientation of the molecule. The “core” moiety is attached to the carbonyl of the amide bond. Six core ring systems can be found which define the current chemical classification for SDHIs. On the amine side of the amide bond, a “linker” is attached. The linker varies but is usually a phenyl group; it may be a simple nonsubstituted phenyl ring (carboxin) or carry substituents at different position