海绵动物的生物活性产物及其药理作用.docxVIP

gy emp loying the fingerp rin t of Ch inese m ateria m edica [J ]1 J T rad it M ed M ater (中药材) , 2001, 24: 2352239. [ 4 ] Q in H L , Shang Y J , Zhao W , et a l. Identificat ion of ch inese go ld th read (Cop tis ch inensis) [J ]1 Chin T rad it H erb D rugs (中草药) , 2000, 31 (1) : 48250. [ 5 ] X ie P S. O n the feasibility of app licat ion of ch rom atograph ic fingerp rin t identificat ion to herbal m edicat ion [J ]1 Chin T ra2 d it P at M ed (中成药) , 2000, 22 (6) : 3912395. [ 6 ] L iu L J , Zhang Q B, Zhang S J. Study on H PL C 2FPS analy2 sis of R ad ix A canthop anacis S enticosi and comparative study on its different sources [J ]1 Chin T rad it P at M ed (中成药) , 2001, 23 (11) : 7812783. [ 7 ] J ia X B, Sh i Y F, Chen Y, et a l. Study on H PL C fingerp rin t of compound R enshen In ject ion [J ]1 Chin T rad it P at M ed (中成药) , 2002, 24 (4) : 2432245. [ 8 ] Zhou X Y, Zhang L X, Zhang L , et a l. Study on H PL C fin2 gerp rin t analysis of F los Cartham i [J ]1 Chin T rad it P at M ed (中成药) , 2002, 24 (5) : 3252327. [ 9 ] L i K, W ang S D , Song B S. F ingerp rin t of Ch inese m ateria m edica and its effects on developm ent of Ch inese m ateria m edica [J ]1 Chin T rad it H erb D rugs ( 中草药) , 2002, 33 (11) : 9612963. 海绵动物的生物活性产物及其药理作用 巫志峰, 许东晖3 , 梅雪婷, 许实波Ξ (中山大学药学院 药物药理研究室, 广东 广州 510275) 摘 要: 概括来源于海洋海绵动物中新发现的 36 种生物活性次生代谢产物, 阐述其化学成分及药理作用的研究进 展。其化学成分具有生物碱、甾醇、萜类、大环内酯、肽类等。经药效评价且有抗菌、抗病毒、抗肿瘤以及心血管活性 等药理作用。 这些具明显药理作用的生理活性化合物, 作为新药先导化合物进行研究开发, 具有良好的应用前景。 关键词: 海绵动物; 生物活性产物; 先导化合物 中图分类号: R 282. 74 文献标识码: A 文章编号: 0253 2670 (2003) 11 附 10 06 Pharmacolog ica l effects of b ioac t ive products from an ima l of mar in e sponge W U Zh i2feng, XU Dong2hu i, M E I Xue2ting, XU Sh i2bo (Sect io n of D rugs and Pha rm aco logy, Co llege of Pha rm acy, Sun Yat2sen U n iversity, Guangzhou 510275, Ch ina) Key words: an im al of m arine sponge; b io active p roducts; l