免疫球蛋白M在鼻咽癌中的表达及其与放疗敏感性的关系-耳鼻咽喉科学专业毕业论文.docxVIP

苴直医型太堂亟±堂焦i金塞(10／24)和80．6％(29／36)，其差异具有统计学意义(Z2=9．573，P0．05)， 苴直医型太堂亟±堂焦i金塞 (10／24)和80．6％(29／36)，其差异具有统计学意义(Z2=9．573，P0．05)， NPC患者gp96蛋白表达在不同性别、年龄、病理类型、分化类型、TNM 分期组间比较差异无统计学意义(尸均O．05)；(6)NPC患者的组织类型、 分化类型、T分期、淋巴转移及临床分期与NPC的放疗敏感性密切相关(尸 均O．05)，而NPC患者性别及年龄与放疗敏感性无明显相关性(尸均 O．05)。结论：(1)IgM和gp96在NPC组织中高表达，提示两者可能与鼻 咽癌的发病机制有关；(2)IgM和gp96的表达水平与NPC放疗敏感性呈 负相关，提示它们可以作为预测NPC患者放疗敏感性的指标；(3)IgM和 gp96在NPC组织中表达呈正相关，同时检测两个指标可能会提高预测NPC 放疗敏感性的准确程度，以便制定更为有效的治疗方案；似)IgM及gp96 蛋白在NPC放疗后颈部残留淋巴结转移肿瘤组织中均存在高表达，同样提 示IgM与p996表达可能与NPC放疗敏感性呈负相关； (5)IgM表达与 NPC的T分期及临床分期负相关，gp96蛋白表达与临床分期呈负相关，即 在NPC早期表达更高，提示它们可能是NPC发生的早期事件；(6)NPC放 疗敏感性与患者临床分期、病理分型密切相关。 关键词：鼻咽癌；免疫球蛋白M；糖蛋白96；放疗敏感性 万方数据 The The relationship between expression of Immunoglobulin M and radiosensitivity in human nasopharyngeal carcinoma Abstract：Objective：More and more studies have reported that immunoglobulins(Ig)were found to be expressed in multiple malignant tumors， and its expression might have promote tumor cell proliferation，transfer and other biological significance．Our early studies have confirmed that ImmunoglobulinM(IgM)ectopic expressed in nasopharyngeal carcinoma (NPC)tissue and cell lines，and anti—human IgM antibody had obvious inhibitory effects on the growth of human NPC HNE．．1 cells and HNE．．1 cells xenografts in nude mice，which suggested that IgM ectopic expressed in NPC has a role of growth factor．In the clinical work different patients with NPC have obvious different sensitivity to radiotherapy．However the relation between NPC ectopic expression of IgM and NPC radiotherapy sensitivity is unclear．Glycoprotein96(gp96)is important molecular chaperone protein in the cell，which belong to heat shock protein 90(HSP90)family，participation in Ig (including IgM)folded and assembly,HSP90 family related signaling pathways involved in cell proliferation and apoptosis．Our early research has found anti-human IgM antibody can inhibit the expression of gp96 protein； Another study confirmed that gp96 highly expressed in NPC ti ssue and th