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Clone Farm【克隆农场】 Factory farming could soon enter a new era of mass production. Companies in the US are developing the technology needed to “clone” chickens on a massive scale. Once a chicken with desirable traits has been bred or genetically engineered, tens of thousands of eggs, which will hatch into identical copies, could roll off the production lines every hour. Billions of clones could be produced each year to supply chicken farms with birds that all grow at the same rate, have the same amount of meat and taste the same. This, at least, is the vision of the US’s National Institute of Science and Technology, which has given Origen Therapeutics of Burlingame, California, and Embrex of North Carolina $4.7 million to help fund research. The prospect has alarmed animal welfare groups, who fear it could increase the suffering of farm birds. That’s unlikely to put off the poultry industry, however, which wants disease resistant birds that grow faster on less food. “Producers would like the same meat quantity but to use reduced inputs to get there,” says Mike Fitzgerald of Origen. To meet this demand, Origen aims to “create an animal that is effectively a clone”, he says. Normal cloning doesn’t work in birds because eggs can’t be removed and implanted, Instead, the company is trying to bulk-grow embryonic stem cells taken from fertilized eggs as soon as they’re laid. “The trick is to culture the cells without them starting to distinguish, so they remain pluripotent,” says Fitzgerald. Using a long-established technique, these donor cells will then be injected into the embryo of a freshly laid, fertilized recipient egg, forming a chick that is a “chimera”. Strictly speaking a chimera isn’t a clone, because it contains cells from both donor and recipient. But Fitzgerald says it will be enough if, say, 95 percent of a chicken’s body develops from donor cells. “In the poultry world, it doesn’t matter if it’s not 100 percent,” he says. Another challenge for Origen is to