外科学与免疫学.pptVIP

Cytokine tumour type cytokine effects and possible and results anti-tumour mechanisms IFNα prolonged remissions possible cytostatic of hairy-cell leukaemia effect on tumour weak effects on increased expression of some carcinomas MHC class I, cytostasis IFNΓ ineffective systemically, increased MHC class I and II remissions of peritoneal macrophage activation carcinoma of the ovary Tc activation, cytostasis IL-2 remissions in renal T-cell activation cancer and melanoma and proliferation NK-cell activation TNFα can reduce ?increased tumour malignant ascites cell adhesion, macrophage and lymphocyte activation Cytokine therapy for tmours Roles for endogenous cytokines in tumour pathogenesis* Cytokine Cellular sources Role in tumour formation Il-1 Macrophages, dendritic cells, B cells, Required for tumour invasion and natural killer cells, keratinocytes angiogenesis Il-6 Macrophages, T cells, B cells, endothelial cells, fibroblasts Requir Il-12 Macrophages, dendritic cells, neutrophils Inhibits chemical carcinogenesis Il-15 Macrophages, dendritic cells Promotes natural killer T cell leukaemias Ifn-γ Natural killer cells, natural killer T cells, Inhibits chemical carcinogenesis; inhibits T cells, B cells, macrophages, dendritic cells lymphomas (especially with perforin); Stat1 and Rag2 inhibit carcinomas M-csf Macrophages, endothelial cells, fibroblasts, bone-marrow stroma Promotes breast cancer invasion Gm-csf Respiratory epithelial cells, T cells, Inhibits lymphomas and carcinomas natural killer cells, natural killer T cells, macrophages, eosinophils, endothelial cells, fibroblasts (with Ifn-γand Il-3) Tnf-α Macrophages, natural killer cells, B cells, Requir T cells, neutrophils, fibroblasts, keratinocytes Mif Macrophages, T cells, eosinophils, fibroblasts, Inhibits p53 tumour-suppressor functions keratinocytes, pituitary Tgf-β T cells, B cells, macrophages,