二恶英暴露对成年男性血清类固醇激素的影响.PDFVIP

中国环境科学 2018,38(6) ：2345~2352 China Environmental Science 二噁英暴露对成年男性血清类固醇激素的影响 沈 斌 1,施丽丽 1,董晶剑 1,冯 昊 1,沈林杰 1,项 菁 1,李文静 1,罗 挺 1,城户照彦 2,孙献亮 1,2*(1.嘉 兴学院医学院,浙江 嘉兴 314001 ；2. 日本金泽大学医药保健学院保健学系, 日本 金泽 9208640) 摘要：为了解二噁英(PCDD/DFs)对成年男性类固醇激素水平的影响,采用高分辨气相色谱 /高分辨质谱联用 (HRGC/HRMS)及液相色谱 -质谱联用 (LC-MS/MS)分析二噁英污染地区成年男性(n=50)及非污染地区成年男性(n=48)血清中 9 种类固醇激素水平和 17 种二噁英同 类物浓度.结果显示成年男性血清中双氢睾酮、睾酮、雌二醇的水平与部分二噁英同类物浓度存在显著性相关.污染地区成年男性双氢睾 酮、睾酮、雌二醇的水平与年龄呈显著性正相关.以上结果表明二噁英暴露导致成年男性类固醇激素中的性激素变化异常. 关键词：二噁英；血清；类固醇激素；成年男性 中图分类号：X18 文献标识码：A 文章编号：1000-6923(2018)06-2345-08 1 1 1 Effect of dioxin exposure on serum steroid hormones in adult male. SHEN Bin , SHI Li-li , DONG Jing-jian , FENG Hao1 1 1 1 1 2 1,2* , SHEN Lin-jie , XIANG Jing , LI Wen-jing , LUO Ting , KIDO Teruhiko , SUN Xian-liang (1.Department of public health, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China ；2. Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 9208640, Japan). China Environmental Science, 2018,38(6)：2345~2352 Abstract ：In order to investigate effect of dioxin exposure on serum steroid hormones in adult male, 17dioxin congeners of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and 9 steroid hormones were analyzed in serum from dioxin polluted area (n=50) and non-polluted area(n=48) by HRGC/HRMS and LC-MS/MS. The results showed that testosterone, estradiol, dihydrotestosterone (DHT), and dihydroepiandrosteron levels were significantly related to concentrations of several dioxin derivatives. Levels of DHT, Testosterone and Estradiol increased significa