低辐射剂量低碘对比剂负荷下兔脑CT灌注成像的可行性研究-影像医学与核医学专业论文.docxVIP

II II 中文摘要 低辐射剂量低对比剂负荷下兔脑 CT 灌注成像的可行性研究 结果：三组方案所得兔脑 CT 灌注成像伪彩图均显示满意。三组方案测得脑 CBF 平均值分别为（44.94±7.74）、（43.98±9.43）、（44.27±1.54）ml/(min·100g)。CBV 平均 值分别为（2.02±0.45）、（2.16±0.52）、（2.16±0.37） ml/100g，MTT 平均值分别为 （3.45±1.09）、（3.39±0.87）、（3.56±1.17）s，三组方案各灌注参数之间差异无统计学 意义。三组扫描增强峰值时大脑中动脉 CT 值分别为（439.83±37.86）、（421.33±30.58）、 （408.67±23.89）HU，SNR 值分别为(17.89±5.89)、（16.59±4.71）、（17.08±3.77），差异无 统计学意义。 结论：低浓度低剂量碘对比剂条件下的兔脑 CT 灌注成像，可降低碘负荷，而对 灌注参数结果及图像质量无明显影响。 关键词：碘对比剂；低浓度；低剂量；体层摄影术，X-线计算机；兔脑灌注成像 作 者：闻 芳 指导教师：胡春洪 PAGE PAGE IV 低辐射剂量低对比剂负荷下兔脑 CT 灌注成像的可行性研究 英文摘要 CT perfusion imaging of rabbit brain with low radiation dose and low contrast agent load in the feasibility study Abstract Part I CT Perfusion imaging of rabbit brain with 70 kV tube voltage in the feasibility study Objective: To evaluate the feasibility of low dose CT perfusion imaging of brain. Materials and Methods: Twenty New Zealand white rabbits underwent cerebral CT perfusion imaging twice with tube voltage 70 kV and tube voltage 80 kV, and the check interval is 24 h. The effective dosage (E)、cerebral perfusion parameters (CBF、CBV、MTT) and image quality indicator (SNR) of middle cerebral artery of each protocol were acquired and compared statistically. Results: The effective dosage of 70 kV group and 80 kV group were 1.91 and 2.93 mSv, the effective dosage of 70 kV group reduced for 34.8% as compared with that of 80 kV. There were no significant differences between the cerebral perfusion parameters acquired at different corresponding ROI. SNR of 70 kV group and 80 kV group were (23.15±5.98) and (21.23±9.18), there were not significant. Conclusion: The effective dosage of 70 kV cerebral CT perfusion imaging could be dramatically reduced and the results of perfusion parameters and image quality were about the same. Key words: Low dose; Tomography, X-ray computed; Rabbit brain perfusion imaging; Effective dosage 英文摘要 低辐射剂量低对比剂负荷下兔脑 CT 灌注成像的可行性研究 Part Ⅱ CT Perfusion imaging of rabbit brain with low concentration