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Hyperthyroidism, HTD Caurses of HTD Graves disease 85% Toxic adenoma (plummer HTD 1~3%) Toxic multinodular goiter Thyroiditis :subacute、Hashimoto、pailess Exogenous HTD: factitious 、iodine-induced Ectopic HTD:struma ovaril Thyroid cancer TSH excess Pitutary thyrotropin(TSH)secreting tumor Pitutary resistanse to thyroid hormons Trophoblastic tumons Graves’ HTD Pathogenesis Presentation Diagnosis Treatment infectionmental trauma immunofunctional disorder overtire Ts ↓ Th ↑ B ↑ TRAb↑ TSH receptor cAMP↑ T3,T4↑ Symptoms high metabolism、excitement、consumption Weight loss (despite a good appetite) Increase in number of bowel movement ,but not diarrhea. Tachycardia at rest Symptoms of heat intolerance,excess perspiration Tremor , nervousness , sleeplessness. Signs Thyrid goiter Exophthalmous Myxedema Diagnosis TRAb、TMAb、TPOAb 60% RAIU test symptoms and signs 40% TT3、TT4、FT3、FT4、TSH Prevalence of thyroid autoantibodies Group TSHRAb (%) hTgAb(%) hTPOAb(%) General population 0 5~20 8~27 Graves’ disease 80~95 50~70 50~80 Autoimmune thyroiditis 10~20 80~90 90~100 Relatives of patients 0 40~50 40~50 Patients with IDDM 0 40 40 Pregnant women 0 14 14 RAIU test Identify false HTD subacute , Hashimoto Screening enzyme defects Thyroid metastastic therapy T4 ( T3 ) suppression test Treatment ATDs Thyroidectomy
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