日产850Kg红霉素生产车间设计.doc

日产850Kg红霉素生产车间设计 摘要Major: Biologiy Engineering Author: Runping Lin Supervisor: Zhiqiang Liu School of Life Sciences Hunan University of Science and Technology 411201 Abstract：The Fermentation Engineering and Equipment Course Design can play the connecting role between the preceding and the following in the practice teaching, and lay a good foundation for the students to work in the factory after graduation. This subject is an initial technological design for Erythromycin with daily output of 850 kilograms.According to the requirement,the process of erythromycin production and the calculation of the mass balance and heat quantity balance are completed. In this subject , all of theprocesses are expounded in detail. All the contents are based on the academic calculations .we refer to the practical designes in companies and make our best to approach to the practice. it mainly includes the production craft each kind of target,the equipment chooses the shapedesign calculation,material of the graduated arm of a steelyard calculation,the water,the electricity,the steam estimate as well as the flow chart design.This designachievement mainly uses the form for the entire factory totalfloor-plan(1),flowchat(1),equipment general arrangement(1),and compilation particular data instruction booklet.. Key word: Erythromycin; Process; Design 目 录 中文摘要 英文摘要 前言 1 绪论 1 1.1 红霉素的理化性质 1 1.1.1名称分类 1 1.1.2理化性质 2 1.1.3 发现和分类 2 1.1.4 作用机理 2 1.1.5 作用与用途 2 1.1.6 性状 2 1.1.7 药理作用 2 1.1.8适应症 3 1.1.9 药物相互作用 3 1.2 发展概况 3 1.3 生产概况 3 1.4 销售概况 4 1.5 前景预测 4 1.5.1临床应用有特色 4 1.5.2市场消费需求大 4 1.5.3 后市发展潜力巨大 5 1.6 菌种选择与培育 5 1.6.1菌种选择 5 1.6.2 菌种培育 5 1.7 培养基的种类及各自成分 5 1.7.1 一般原则 5 1.7.2 碳源 5 1.7.3 氮源 5 1.7.4 无机盐和微量元素 6 1.7.5 水 6 1.7.6 生长因子 6 1.7.7 前体与促进剂 6 1.7.8 本设计中培养基的具体情况 6 1.8 中间补料 7 1.9 本设计的工艺原则和流程的确定 9 2 各类物质的用量、热量、空气的计算及设备计算和选型 10 2.1 物料衡算 10 2.1.1 提取的一般工艺流程 10 2.1.2 淋洗过程 10 2.1.3 成盐过程 11 2.1.4 丁提过程 11 2.1.5 板框过滤过程 11 2.1.6 碱化工程（发酵液的预处理） 11 2.1.7 发酵罐（大罐）中各物质的计算 12 2.1.8 中罐中各物质的计算 13 2.1.9 小罐中各物