β-Catenin和APC蛋白在宫颈上皮内瘤样变及宫颈鳞癌中表达及意义-妇产科学专业论文.docxVIP

PAGE PAGE VI Expression and Significance of β-catenin and APC in CIN and Cervical Squamous Cell Carcinoma Abstract was 79.2%，50 cases of CIN APC positive in 23 cases，the positive rate was 46%，30 cases of cervical cancer expression four cases，the positive rate was 13.3%.The results showed that in the normal control group，CIN and cervical carcinoma APC positive rate trend was decreasing，The positive rate of normal cervical mucosa，CIN and cervical squamous cell carcinoma were statistically significant。but the difference among CIN1， CIN2，CIN3 was not statistically significant. In cervical squamous cell carcinoma cases，the abnormal expression ofβ -Catenin and the negative expression of APC both have nothing to do with gender，age， tumor size and tumor site （P0.05）. Among 30 cases of cervical squamous cell carcinoma，bothβ-catenin and APC are negative in 26 cases and positive in 2 cases. A significantly positive relationship was observed between β-Catenin and APC protein expression in cervical carcinoma（P＜ 0.01）。 Conclusion． Normal cervical mueosaβ-Catenin protein expression of the membrane， cytoplasm CIN mainly for the expression of cervical cancer for cytoplasmic /nuclear expression of the abnormal expression rates were 12.5%，42% and 93.3%，group differences were statistically significant. Among them ， high-level intraepithelial neoplasia CIN and high differentiated squamous cell carcinoma mainly cytoplasmic expression of poorly differentiated carcinoma cytoplasm ， the nucleus were expressed.Tipβ-Catenin protein expression changes to a certain extent，reflect the malignant cervix epithelial tissue level，the high-level intraepithelial neoplasia CIN to a certain extent，already have some characteristics of cervical carcinoma.β-Catenin protein expression and the incidence of cervical cancer，is closely related to the development，may be an early event in cervical carcinoma . APC gene in CIN and carcinoma tissue cervix mucosa were significantly lower than that in cervix