当今我国动脉血管硬化的危险因素-英文.ppt

ECA ICA BULB CCA Transverse Plane of CCA, Bulb, ECA, ICA BULB CCA ECA ICA * CATHAY Cohort: Carotid Intima-media Thickness Cathay Study Result * * * * * * 1.????????? we use high resolution B mode ultrasonography to documentate the therapeutic effects of our drug. 1.????????? IMT is the measurement of carotid Intima-media thickening 2.????????? Which is correlates well with severity and extent of coronary artery disease 3.????????? EDD is the measurement of endothelium dependant dilation 4.????????? Which is correlates with vascular reactivity of brachial artery 5.????????? Both IMT and EDD are sensitive and surrogate marker of cardiovascular events and mortality. * * 50 healthy vegetarians who are persistent for vegetarian diet for at least 10 years were recruited. They were underwent double-blinded randomization into two groups. The first group received 1capsule of 500ug B12 per day for 12 weeks. At the same time the second group subjects received identical placebo (1capsule) per day for 12 wks. After the first 12 wks, there were 10 weeks for washout. Then the crossover occurred, the first group of subject would assigned for placebo (1 capsule per day) for 12 wks again. While the second group received the B12 (500ug) per day for 12 wks this time. * 1.????????? we use high resolution B mode ultrasonography to documentate the therapeutic effects of our drug. 1.????????? IMT is the measurement of carotid Intima-media thickening 2.????????? Which is correlates well with severity and extent of coronary artery disease 3.????????? EDD is the measurement of endothelium dependant dilation 4.????????? Which is correlates with vascular reactivity of brachial artery 5.????????? Both IMT and EDD are sensitive and surrogate marker of cardiovascular events and mortality. * * * Genes External Environment Internal Environment Endothelial Intima-Media Dysfunction Thickening Atherosclerotic Disease Dietary Habits: Green Tea Vegetables Carotene Folate Animal Protein