mFOLFOX6方案与PF方案同步放疗治疗非手术食管癌近期疗效观察.docVIP

mFOLFOX6方案与PF方案同步放疗治疗非手术食管癌近期疗效观察 　　【摘要】 目的 ?Ρ确鞘质跏彻馨┗颊卟扇?mFOLFOX6方案同步放化疗与传统PF方案同步放化疗的疗效差异。方法 60例Ⅱ/ Ⅲ 期非手术食管鳞癌患者， 随机分为试验组（27例）和对照组（33例）。两组均采用三维适形放疗（3D-CRT）。试验组放疗期间予以mFOLFOX6方案同步化疗， 对照组放疗期间予以PF方案同步化疗。分析两组近期疗效、治疗毒性反应。结果 试验组近期总有效率为92.59%， 高于对照组的75.76%， 但差异无统计学意义（P0.05）。两组主要毒性为骨髓抑制、消化道反应及神经毒性反应。骨髓抑制主要表现为白细胞减少， 其中试验组Ⅲ～Ⅳ度骨髓抑制发生率为22.2%（6/27）， 对照组为27.3%（9/33）， 比较差异无统计学意义（P0.05）。消化道反应主要表现为放射性食管炎、恶心、呕吐。两组均未发生Ⅲ度以上食管炎；试验组恶心、呕吐发生率29.6%（8/27） 对照组为60.6%（20/33）， 比较差异有统计学意义（P=0.0170.05）。所有不良反应经对症治疗后均可缓解， 患者能良好耐受。结论 与传统PF方案同步放化疗比较， mFOLFOX6方案同步放化疗治疗非手术食管鳞癌患者近期总有效率较高， 近期疗效好， 不良反应可耐受， 值得进一步研究。 　　【关键词】 非手术食管癌；同步放化疗；mFOLFOX6方案；PF方案 　　DOI：10.14163/j.cnki.11-5547/r.2017.08.012 　　【Abstract】 Objective To compare difference of curative effects between mFOLFOX6 regimen radiochemotherapy and PF regimen in concurrent radiochemotherapy for non-operative esophagus cancer patients. Methods A total of stage Ⅱ/Ⅲ non-operative esophagus squamous carcinoma patients were randomly divided into experimental group （27 cases） and control group （33 cases）. Both groups received three-dimensional conformal radiation therapy （3D-CRT）. The experimental group received mFOLFOX6 regimen radiochemotherapy in treatment， and the control group received PF regimen in concurrent radiochemotherapy instead. Analysis was made on short-term curative effect and toxic reactions in treatment in the two groups. Results The experimental group had higher short-term total effective rate as 92.59% than 75.76% in the control group， while their difference had no statistical significance （P0.05）. Main toxic reactions in both groups included myelosuppression， gastrointestinal reactions and neurotoxic reactions， with leucopenia as the main manifestation in myelosuppression. The experimental group had incidence of grade Ⅲ～Ⅳ myelosuppression as 22.2% （6/27）， which was 27.3% （9/33） in the control group， and the difference had no statistical significance （P0.05）. Main manifestations of gastrointestinal reactions included radiation esopha