中国水利水电三工程局有限公司工会...10.pptVIP

Clonal Diversification of Lymphocytes; Review of last lecture;Bone Marrow ; Antigen; B Cell clone #2 ; B Cell clone #2 ;Multiclonal Stimulation Activation of specific clones of B cells Polyclonal Activation (non-specific activation of all B cell clones in the area by i.e., endotoxic LPS);Poly-CARBOHYDRATE ANTIGEN - repeating antigenic determinants ;Helper T Cells Cytotoxic T Cells; Helper T Cell clones ;Bind in some cases via surface antibody (sometimes passively absorbed) or via complement deposited on the antigen then Phagocytize the antigen (see the lecture handout). Followed by DIGESTION of the antigen that must occur without infecting the cell. Note Ab and complement neutralize the antigen. Antigen Presenting Cells DO NOT Have T Cell Receptors;All types of Antigen Presenting Cells (APC) continually produce Major Histocompatibility Complex Class II Products(MHC Class 2 Products) that are produced inside the cell move to the surface then and stay on the cell surface; These MHC 2 products are only on cells which digest and then present the digested fragments of the antigens to Helper T cells;Types of Antigen Presenting Cells: Macrophages and Macrophage-like cells Dendritic Cells (And Pre-dendritic Cells) B Cells (B lymphocytes);Types of Antigen Presenting Cells: Macrophages and Dendritic Cells have Fc-Receptors and Complement Receptors. Thus these types of APC also can become Armed with low levels of polyclonal Ab-Ag complexes via the Ab that may be weakly fitting (very weak affinity) at the beginning of the infection B Cells (B lymphocytes)-- monoclonal Ab;Antigen Presenting Cell must bind and digest the antigen;Major Histocompatibility Complex (MHC)Class 2 Molecule;Major Histocompatibility Complex MHC Class 2 Molecule;Helper T Cell With a correct T Cell Receptor CD4+ ;Helper T Cell With a correct T Cell Receptor CD4+ ;Major Histocompatibility Complex Products MHCAlso termed HLA Human Leukocyte