Involved in Determining susceptibility to Crohns Disease参与确定克罗恩病的易感因素ppt课件.pptVIP

Crohn’s Disease;Inflammatory Bowel Disease (IBD) Inflammation, swelling, and irritation of GI tract Approximately 0.5% of the Canadian population have an IBD, highest reported prevalence rate Jewish, highest risk; African Americans, lower risk Prognosis: condition marked by periods of improvement followed by flare-ups Diagnosed between ages 13-30 Autoimmune disease Decreased suppression of immune response for enteric bacteria and self-antigens  ;SYMPTOMATOLOGY ;COMPLICATIONS ;TYPES ;DIAGNOSTIC TESTS ;Factors Involved in Determining susceptibility to Crohn’s Disease;Genetic Susceptibility 1: Healthy Individuals;Genetic Susceptibility : Healthy Individuals;Genetic Susceptibility 2: Healthy Individuals;Genetic Susceptibility 3: Healthy Individuals;Genetic Susceptibility:Individuals with Crohn’s Disease;Environmental Triggers and response;Individual Immune Response;Cells To Know;In A Healthy Individual;What Happens When Mucosal T-cells Are Activated In a Healthy Individual?;;In Crohn’s Disease;Events Associated by Cytokines Release from TH1 Cells;Role of IL-6 in Crohn’s Disease;;Role of TNF-α in Crohn’s Disease;TREATMENT MANAGEMENT;DIET NUTRITION;DRUG THERAPY;AMINOSALICYLATES;CORTICOSTEROIDS;MERCAPTOPURINE;TNF-α INHIBITORS;ANTI-TNF-α MONOCLONAL ANTIBODIES;SURGERY;Summary;References