北京大学图书馆中文核心期刊目录(2048.pptVIP

Safeguarding against the harmful misuse of research:A research funder’s perspective David Carr The Wellcome Trust (d.carr@wellcome.ac.uk) Overview Introduction to the Wellcome Trust The policy context Wellcome Trust position statement Follow-on work The Wellcome Trust Our mission Concerns over research misuse: key policy developments The key issues Experiments of concern Demonstrate how to render a vaccine ineffective Confer resistance to therapeutically-useful antibiotics or antiviral agents Enhance the virulence of a pathogen or render a non-pathogen virulent Increase the transmissibility of a pathogen Alter the host-range of a pathogen Enable the evasion of diagnostic/detection modalities Enable weaponization of a biological agent or toxin The need to support research The Wellcome Trust is a major funder of research on: immunology and infectious diseases tropical medicine genome sequencing (e.g. malaria, TB, typhoid, plague) Research which is desperately needed… Global health burden of both long-standing and newly-emerging infectious diseases Demand for drugs, vaccines, diagnostics and control strategies Advances in biomedical science offer tremendous potential to deliver new solutions Wellcome Trust response Balancing benefit and risk Dissemination of research outcomes International co-operation in science Promoting self-regulation The scientific community can develop effective systems of self regulation to manage risks of misuse The community as a whole should work proactively to further develop such systems. Discussions need to involve all stakeholder groups (scientists, regulators, administrators, funders, etc) It is crucial that the community acts to ensure that its members are aware of these concerns and of their legal and ethical responsibilities A code of conduct? Moving forwards Considering risks of misuse in grant funding processes A strong existing framework Funding decisions are based on peer review by leading experts in the field (external r