钩端螺旋体病课件_23.pptVIP

Leptospirosis General Review Etiology Epidemiology Pathogenesis and Pathology Clinical Manifestations Diagnosis Treatment and Prevention Etiology: Morphology Thin, flexible, finely coiled with a hook at the end Gram-Negative, Giemsa stain: Light red 0.1μm in diameter 6-20μm in length Etiology: Picture (dark-field microscope) Motility can be seen It is characterized by very active motility, by roating and bending Etiology: Culture Obligate aerobic, slow growing Cultured in Korthol media enriched with rabbit serum or albumin, at 30 ℃ and an optimal PH 7.2 to 7.6， their generation time varies from 7 to 12 hours It can be isolated by intraperitoneally inoculating of young guinea-pig Etiology: Resistance It is sensitive to dry, suds, ethanol and bleaching powder Survive in damp soil and water for 4 wks-3 mths Etiology: Classfication 23 Serogroups, 200 serotypes 19 Serogroups and 74 serotypes in China The most common serogroups: L. icterohemorrhagic(黄疸出血群) L. pomona(波摩那群) L. canicola(犬群) L. hebdomadis(七日热群) Widest distribution in China : L.pomona L. icterohemorrhagic causes the most severe illness Epidemiology In 1886, Weil, a German doctor observed 4 cases of leptospirosis with jaundice, than this disease is called as Weil disease In China: in 1937, Professor Tang zeguang (汤泽光)discovered leptospirosis in Guangzhou Epidemiology： Source of Infection Reservoirs of infection: rodents, domestic livestock (swine and cattle), dogs and foxes Source of infection Livestock：swine,dogs, cattle,sheep,horses Wild animals：rats(Apodemus agarius,黑线姬鼠), rabbits,wolfs,snakes and frogs  The main source of Infection： Apodemus agariu: L.icterohemorrhagic. Field style in south of China Swine: L. pomona. Flood style and raining style in north of China Epidemiology ：  Routes of transmission Infected animals excrete leptospiras in the urine Exposure to the water, soil or plants contaminated by urine of Infected animals Direct contact with infected anima