血必净注射液对重症肺炎患者的疗效与其对细胞免疫与炎症因.docVIP

血必净注射液对重症肺炎患者的疗效及其对细胞免疫及炎症因子的影响 陈山 海南省农垦总医院呼吸内科， 【关键词】血必净；重症肺炎；免疫；炎症因子 Effect its effect on cellular immunity and inflammatory factors of Xuebijing Injection on patients with severe pneumonia CHEN Shan (Respirology?Department, Hainan agricultural reclamation general hospital, Hainan Haikou 570311) [Abstract] Objective: To study the clinical curative effect of Xuebijing Injection on patients with severe pneumonia, to observe the effect on cellular immunity and inflammatory factors, to provide basis for clinical treatment. Methods: 110 cases of severe pneumonia in our hospital from January 2014 to February 2016 were selected, the patients were divided into the study group and the control group, 55 cases in each group, the control group received routine treatment, the study group plus Xuebijing injection treatment, the clinical effect of two groups were compared, interleukin 1 (IL-1) and interleukin 6 (IL-6), tumor necrosis factor-A (TNF-a), CD4 +, CD8 + and natural killer (NK) cells before and after treatment in two groups were compared. Results: The total effective rate of the study group was 83.6% (53/55) was significantly higher than that of 83.6％(46/55) in the control group (P0.05); after treatment IL-1, IL-6 and TNF-a of two groups were significantly lower than those before treatment (P0.05), and the study group was significantly lower than the control group (P0.05); after treatment CD4+ and NK cells of two groups were significantly increased (P0.05), CD8+ was significantly lower than before treatment (P0.05), CD4+ and NK in the study group were significantly higher than those in the control group (P0.05), CD8+ was significantly lower than the control group (P 0.05). Conclusion: Xuebijing injection in the treatment of severe pneumonia has good clinical curative effect, can reduce the inflammatory reaction, enhance the patients cellular immunity. [Key words] Xuebijing; Severe pneumonia; Immune; Inflammation factor 重症肺炎是临床上较严重的常见疾病，患者较容易出现呼吸衰竭、全身炎症反应综合征、多脏器功能衰竭等，具