RESPONSES TO REVIEWER Gerstein Lab Publication反应者格斯坦实验室出版物.docVIP

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RESPONSES TO REVIEWER Gerstein Lab Publication反应者格斯坦实验室出版物.doc

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RESPONSES TO REVIEWER Gerstein Lab Publication反应者格斯坦实验室出版物

Response Letter -- Editor-1 – Abstract too long -- Reviewer Comment The abstract is too long and should be ~100 words-so I suggest you move the marked section until later. Author Response We changed the abstract according to the editor’s comments on the marked manuscript. Excerpt From Revised Manuscript [Abstract] From merging a number of data sources, we created an extensive map of the transcriptional regulatory network in yeast, comprising 7419 interactions connecting 180 transcription factors (TFs) with their target genes. We integrated this network with gene-expression data, relating the expression profiles of TFs and target genes. We found that genes targeted by the same TF tend to be co-expressed, with the degree of co-expression increasing if genes share more than one TF. Moreover, shared targets of a TF tend to have similar cellular functions. In contrast, the expression relationships between the TFs and their targets are much more complicated, often exhibiting time-shifted or inverted behavior. -- Editor-2 – Reference style -- Reviewer Comment The reference articles need titles Author Response We changed the reference style accordingly. Excerpt From Revised Manuscript [Reference] 1 Schena, M., Shalon, D., Davis, R.W. and Brown, P.O. (1995) Quantitative monitoring of gene expression patterns with a complementary DNA microarray. [see comments.]. Science 270, 467-70 2 Chee, M. et al. (1996) Accessing genetic information with high-density DNA arrays. Science 274, 610-4 … -- Editor-3 – Other microarray datasets -- Reviewer Comment Referee 1 makes the point you have only looked at the cell-cycle. Would it be an idea to extend the analysis to one other condition? Author Response The referee and the editor are right in that some transcription factors only activate (or repress) their targets in response to specific conditions (sporulation, heat-shock, etc). In this sense, we should extend the analysis to other conditions. However, we have shown that the re