Graph Theoretical Insights into Evolution of Multidomain Proteins图的理见解的多结构域蛋白质的进化.pptVIP

下载本文档

3
0
约9.02千字
约 44页
2018-06-19 发布于福建
举报
版权申诉

Graph Theoretical Insights into Evolution of Multidomain Proteins图的理见解的多结构域蛋白质的进化.ppt

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Graph Theoretical Insights into Evolution of Multidomain Proteins图的理见解的多结构域蛋白质的进化

DIMACS, May 2006 Towards uncovering dynamics of protein interaction networks Teresa Przytycka NIH / NLM / NCBI Investigating protein-protein interaction networks Functional Modules and Functional Groups Functional Module: Group of genes or their products in a metabolic or signaling pathway, which are related by one or more genetic or cellular interactions and whose members have more relations among themselves than with members of other modules (Tornow et al. 2003) Functional Group: protein complex (alternatively a group of pairwise interacting proteins) or a set of alternative variants of such a complex. Functional group is part of functional module Challenge Within a subnetwork (functional module) assummed to contain molecules involved in a dynamic process (like signaling pathway) , identify functional groups and partial order of their formation Computational Detection of Protein Complexes Spirin Mirny 2003, Rives Galitski 2003 Bader et al. 2003 Bu et al. 2003 … a large number of other methods Common theme : Identifying densely connected subgraphs. Protein interactions are not static Signaling pathways Previous work on detection of Signaling Pathways via Path Finding Algorithms Steffen et al. 2002; Scott et al. 2005 IDEA: The signal travels from a receptor protein to a transcription factor (we may know from which receptor to which transcription factor). Enumerate simple paths (up to same length, say 8, from receptor(s) to transcription factor(s) Nodes that belong to many paths are more likely to be true elements of signaling pathway. Pheromone signaling pathway Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups Overlaps between Functional Groups First line of attack First line of attack First